维生素 D 与青少年黄体中期雌二醇和孕酮的关系。

The relation between vitamin D and the adolescents' mid-luteal estradiol and progesterone.

机构信息

Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.

出版信息

Eur Rev Med Pharmacol Sci. 2023 Jul;27(14):6792-6799. doi: 10.26355/eurrev_202307_33150.

DOI:10.26355/eurrev_202307_33150

PMID:37522690

Abstract

OBJECTIVE

The aim of this study was to detect the effect of vitamin D (Vit. D) intake on the mid-luteal estradiol (E2), and progesterone (P), and the relation between vit. D, and the adolescents' mid-luteal E2, and P.

PATIENTS AND METHODS

Eighty-five (85) adolescents were recruited for this cohort study after obtaining informed consent. After a detailed history and clinical examination, the body mass index (BMI) of the studied participants was calculated, followed by pelvic sonography to exclude any pelvic pathology. Participants' blood samples were collected on days 21-22 of the menstrual cycle (mid-luteal) to measure the thyrotropin (TSH) (i.e., to exclude hypothyroidism), prolactin (i.e., to exclude hyperprolactinemia), glycosylated hemoglobin (HbA1C), (i.e., to exclude diabetes), E2, P, and 25(OH)D. Participants received 50,000 IU of vit. D weekly for two months, and on the 3rd month, the mid-luteal E2, P, and 25(OH)D were measured. The mid-luteal E2, P, and 25(OH)D were compared before and after the vit. D intake to detect the effect of vit. D intake (50,000 IU weekly for 2 months) on the mid-luteal E2 and P (primary outcome). Additionally, the relations between vit. D and the adolescents' mid-luteal E2 and P were detected as secondary outcomes using the correlation analysis (Pearson's correlation).

RESULTS

The mid-luteal E2 and P statistically decreased from 109.3±15.7 pg/mL and 9.8±1.01 ng/mL, respectively to 40.7±10.52 pg/mL, and 5.2±0.73 ng/mL, respectively, after vit. D intake (p=0.00015; 95% CI: 64.5, 68.6, 72.7, and p=0.0016; 95% CI: 4.3, 4.6, 4.87, respectively). Significant negative correlations between the 25(OH)D, and both the mid-luteal E2 (r -0.661; p<0.00001), and P (r -0.521; p<0.00001) were detected in this study.

CONCLUSIONS

The mid-luteal E2 and P statistically decreased after vit. D intake (50,000 IU of vit. D weekly for 2 months). Significant negative correlations between the 25(OH)D, and both the mid-luteal E2 and P were detected in this study. The relation between vit. D and ovarian steroids, and the effect of vit. D intake on ovarian steroids need further larger studies.

摘要

目的

本研究旨在检测维生素 D（Vit. D）摄入对黄体中期雌二醇（E2）和孕酮（P）的影响，以及维生素 D 与青少年黄体中期 E2 和 P 之间的关系。

患者和方法

在获得知情同意后，本研究招募了 85 名青少年进行这项队列研究。在详细的病史和临床检查后，计算了研究参与者的体重指数（BMI），随后进行盆腔超声检查以排除任何盆腔疾病。参与者的血液样本在月经周期的第 21-22 天（黄体中期）采集，以测量促甲状腺激素（TSH）（即排除甲状腺功能减退）、催乳素（即排除高催乳素血症）、糖化血红蛋白（HbA1C）（即排除糖尿病）、E2、P 和 25（OH）D。参与者每周接受 50,000 IU 的 Vit. D 治疗两个月，在第三个月测量黄体中期的 E2、P 和 25（OH）D。比较 Vit. D 摄入前后的黄体中期 E2、P，以检测 Vit. D 摄入（每周 50,000 IU 连续两个月）对黄体中期 E2 和 P 的影响（主要结果）。此外，还使用相关性分析（Pearson 相关性）作为次要结果检测 Vit. D 与青少年黄体中期 E2 和 P 之间的关系。

结果

与 Vit. D 摄入前相比，黄体中期 E2 和 P 分别从 109.3±15.7 pg/mL 和 9.8±1.01 ng/mL 统计学下降至 40.7±10.52 pg/mL 和 5.2±0.73 ng/mL（p=0.00015；95%CI：64.5，68.6，72.7，p=0.0016；95%CI：4.3，4.6，4.87，分别）。本研究还检测到 25（OH）D 与黄体中期 E2（r=-0.661；p<0.00001）和 P（r=-0.521；p<0.00001）之间存在显著负相关。