Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
J Med Life. 2023 Nov;16(11):1597-1605. doi: 10.25122/jml-2023-0248.
Dysmenorrhea, affecting approximately 80% of adolescents, significantly impairs quality of life, disrupts sleep patterns, and induces mood changes. Furthermore, its economic impact is substantial, accounting for an estimated $200 billion in the United States and $4.2 million in Japan annually. This review aimed to identify the effects of vitamin D and calcium on primary dysmenorrhea. We conducted a comprehensive literature search across Web of Science, PubMed, Scopus, and Science Direct, focusing on studies published from 2010 to 2020. Keywords included 'primary dysmenorrhea', 'vitamin D', '25-OH vitamin D3', 'cholecalciferol', and 'calcium'. The quality assessment of the articles was done using the Consolidated Standards of Reporting Trials (CONSORT) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklists, and the risk bias was assessed using the Cochrane assessment tool. Abnormal low Vit. D levels increased the severity of primary dysmenorrhea through increased prostaglandins and decreased calcium absorption. Vitamin D and calcium supplements could reduce the severity of primary dysmenorrhea and the need for analgesics. This systematic review found an inverse relation between the severity of dysmenorrhea and low serum Vit. D and calcium.. Vitamin D and calcium supplements could reduce the severity of primary dysmenorrhea and the need for analgesics.
痛经影响了大约 80%的青少年，严重影响了他们的生活质量，打乱了他们的睡眠模式，并导致情绪变化。此外，它还造成了巨大的经济影响，在美国估计每年造成 2000 亿美元的损失，在日本造成 420 万美元的损失。本综述旨在确定维生素 D 和钙对原发性痛经的影响。我们在 Web of Science、PubMed、Scopus 和 Science Direct 上进行了全面的文献检索，重点关注了 2010 年至 2020 年期间发表的研究。关键词包括“原发性痛经”、“维生素 D”、“25-羟维生素 D3”、“胆钙化醇”和“钙”。文章的质量评估使用了 CONSORT 和 STROBE 检查表，风险偏倚使用了 Cochrane 评估工具。异常低的 Vit.D 水平通过增加前列腺素和减少钙吸收来增加原发性痛经的严重程度。维生素 D 和钙补充剂可以减轻原发性痛经的严重程度和对止痛药的需求。这项系统评价发现痛经的严重程度与血清 Vit.D 和钙水平低之间存在反比关系。因此，维生素 D 和钙补充剂可以减轻原发性痛经的严重程度和对止痛药的需求。
