Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine.
Rehabilitation Medicine Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine.
J Vis Exp. 2023 Jul 14(197). doi: 10.3791/65535.
Neuropathic pain is a prevalent condition that affects 6.9%-10% of the population and results from nerve damage due to various etiologies, such as lumbar disc herniation, spinal canal stenosis, and intervertebral foramen stenosis. Although Tuina, a traditional Chinese manual therapy, has shown analgesic effects in clinical practice for the treatment of neuropathic pain, its underlying neurobiological mechanisms remain unclear. Animal models are essential for elucidating the basic principles of Tuina. In this study, we propose a standardized Tuina protocol for rats with compression of the dorsal root ganglion (DRG), which involves inducing DRG compression by inserting a stainless steel rod into the intervertebral foramen, performing Tuina manipulation with specific parameters of location, intensity, and frequency in a controlled environment, and assessing the behavioral and histopathological outcomes of Tuina treatment. This article also discusses the potential clinical implications and limitations of the study and suggests directions for future research on Tuina.
神经性疼痛是一种普遍存在的病症，影响着 6.9%-10%的人群，它是由各种病因引起的神经损伤导致的，如腰椎间盘突出症、椎管狭窄症和椎间孔狭窄症。尽管推拿，一种传统的中医手法治疗，在临床实践中已经显示出对神经性疼痛的镇痛效果，但它的潜在神经生物学机制仍不清楚。动物模型对于阐明推拿的基本原理至关重要。在这项研究中，我们提出了一种标准化的用于大鼠背根神经节（DRG）受压模型的推拿方案，该方案通过将不锈钢棒插入椎间孔来诱导 DRG 压迫，在受控环境中使用特定的位置、强度和频率参数进行推拿操作，并评估推拿治疗的行为和组织病理学结果。本文还讨论了该研究的潜在临床意义和局限性，并为推拿的未来研究提出了方向。
