Post Graduate Institute of Dental Sciences, Rohtak, Haryana, 124001, India.
Post Graduate Institute of Medical Sciences, Rohtak, Haryana, 124001, India.
Clin Oral Investig. 2023 Sep;27(9):5617-5625. doi: 10.1007/s00784-023-05183-z. Epub 2023 Jul 31.
The objective of this study is to investigate the effect of endodontic treatment on flow-mediated dilatation (FMD) and carotid intima-media thickness (c-IMT) in patients with apical periodontitis (AP).
The study includes 32 young men having AP with a mean age of 25.78 years free from cardiovascular disease (CVD) and its risk factors, including periodontitis. All subjects underwent complete physical and dental examination, echocardiography, and ultrasound assessment of FMD on the brachial artery and c-IMT on the carotid artery at baseline and 12 months after the endodontic treatment. Data were analyzed using paired Student's t-test and Pearson's correlation coefficient (r) test using SPSS 26 version.
Endodontic treatment leads to the improvement of FMD significantly from a pooled baseline value of 4.84 ± 1.55% to 7.68 ± 2.08% (p < 0.05). The study also depicts a statistically significant difference between c-IMT (mean = 0.62 ± 0.11 mm) before treatment as compared to 12 months after treatment (mean = 0.59 ± 0.11 mm) (p < 0.05).
Endodontic treatment leads to improved FMD and decreased c-IMT suggesting that treating AP can be help revert the early stages of CVD.
AP could be a potential etiological factor of future CVD and should be treated as soon as diagnosed.
本研究旨在探讨根尖周炎（AP）患者根管治疗对血流介导的舒张功能（FMD）和颈动脉内膜中层厚度（c-IMT）的影响。
本研究纳入了 32 名年龄在 25.78 岁左右、无心血管疾病（CVD）及其危险因素（包括牙周炎）的年轻男性 AP 患者。所有受试者均接受了完整的体格检查和牙科检查、超声心动图检查，并在基线和根管治疗后 12 个月时分别进行了肱动脉 FMD 和颈动脉 c-IMT 的超声评估。采用配对 Student's t 检验和 Pearson 相关系数（r）检验对数据进行分析，采用 SPSS 26 版进行分析。
根管治疗可显著改善 FMD，从基线时的 4.84±1.55%增加到治疗后的 7.68±2.08%（p<0.05）。研究还表明，治疗前 c-IMT（平均=0.62±0.11 mm）与治疗后 12 个月时的 c-IMT（平均=0.59±0.11 mm）之间存在统计学差异（p<0.05）。
根管治疗可改善 FMD 并降低 c-IMT，提示治疗 AP 可以逆转 CVD 的早期阶段。
AP 可能是未来 CVD 的潜在病因，一旦确诊应尽快治疗。
