以锍盐或碘化亚砜鎓盐作为甲基化试剂，可便捷地制备甲基二硫代氨基甲酸盐。
Facile access to -methyl dithiocarbamates with sulfonium or sulfoxonium iodide as a methylation reagent.
作者信息
Deng Huiying, Xiang Lingling, Yuan Zhijun, Lin Bohong, He Yiting, Hou Qi, Ruan Yaoping, Zhang Jing
机构信息
Artemisinin Research Center and The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China.
出版信息
Org Biomol Chem. 2023 Aug 16;21(32):6474-6478. doi: 10.1039/d3ob00932g.
Efficient access to -methyl dithiocarbamates was achieved with sulfonium or sulfoxonium iodide as a methylation reagent. This method is reliable for the synthesis of dithiocarbamates from primary or secondary amines, with sulfoxonium iodide demonstrating more robust methylation capability than sulfonium iodide. Moreover, it also enables facile access to -trideuteromethyl dithiocarbamates sulfoxonium metathesis between sulfoxonium iodide and DMSO- with high yields.
使用碘化锍或碘化锍盐作为甲基化试剂可高效获得 - 甲基二硫代氨基甲酸盐。该方法对于由伯胺或仲胺合成二硫代氨基甲酸盐是可靠的，碘化锍盐显示出比碘化锍更强的甲基化能力。此外，它还能通过碘化锍盐与二甲基亚砜之间的锍盐复分解反应，以高产率轻松获得 - 三氘代甲基二硫代氨基甲酸盐。
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