通过环状锍盐与CS和胺的多组分反应合成α-烷基二硫代氨基甲酸盐。
Synthesis of -Alkyl Dithiocarbamates via Multicomponent Reaction of Cyclic Sulfonium Salts with CS and Amines.
作者信息
Yang Li, Shu Jia, Liu Yun, Jin Yuan-Xin, Chen Si Si, Huang Wei, Xu Xiang-Qin, Xie Long-Yong
机构信息
Key Laboratory of Comprehensive Utilization of Advantage Plants Resources of Southern Hunan, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China.
College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China.
出版信息
J Org Chem. 2024 Oct 18;89(20):15248-15263. doi: 10.1021/acs.joc.4c02063. Epub 2024 Oct 3.
A convenient and practical method for the synthesis of various -alkyl dithiocarbamates through three-component reaction of sulfonium salts, CS and amines has been developed. The reaction proceeds efficiently without any catalyst and additive under mild and open-air conditions, making it potential applications in pharmaceutical chemistry and sulfur chemistry.
通过锍盐、CS和胺的三组分反应合成各种烷基二硫代氨基甲酸盐的便捷实用方法已被开发出来。该反应在温和的露天条件下无需任何催化剂和添加剂即可高效进行，使其在药物化学和硫化学方面具有潜在应用。
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