Department of Pathology, Duke University School of Medicine and Duke Cancer Institute, Durham, North Carolina.
NCI, NIH, Bethesda, Maryland.
Mol Cancer Ther. 2023 Oct 2;22(10):1144-1153. doi: 10.1158/1535-7163.MCT-22-0714.
The Cooperative Human Tissue Network was created by the NCI in 1987 to support a coordinated national effort to collect and distribute high quality, pathologist-validated human tissues for cancer research. Since then, the network has expanded to provide different types of tissue samples, blood and body fluid samples, immunohistologic and molecular sample preparations, tissue microarrays, and clinical datasets inclusive of biomarkers and molecular testing. From inception through the end of 2021, the network has distributed 1,375,041 biospecimens. It served 889 active investigators in 2021. The network has also taken steps to begin to optimize the representation of diverse communities among the distributed biospecimens. In this article, the authors review the 35-year history of this network, describe changes to the program over the last 15 years, and provide operational and scientific highlights from each of the divisions. Readers will learn how to engage with the network and about the continued evolution of the program for the future.
美国国立卫生研究院（NCI）于 1987 年创建了合作人类组织网络，以支持协调一致的国家努力，收集和分发高质量、经过病理学家验证的人类组织用于癌症研究。自那时以来，该网络已经扩展，提供了不同类型的组织样本、血液和体液样本、免疫组织化学和分子样本制备、组织微阵列以及包含生物标志物和分子检测的临床数据集。从成立到 2021 年底，该网络已分发了 1375041 个生物样本。2021 年，该网络为 889 名活跃研究人员提供了服务。该网络还采取措施，开始优化分布的生物样本中不同社区的代表性。在本文中，作者回顾了该网络 35 年的历史，描述了过去 15 年计划的变化，并提供了每个部门的运营和科学亮点。读者将了解如何与网络互动以及该计划未来的持续发展。
