Petracca M, Carotenuto A, Scandurra C, Moccia M, Rosa L, Arena S, Ianniello A, Nozzolillo A, Turrini M, Streito L M, Abbadessa G, Cellerino M, Bucello S, Ferraro E, Mattioli M, Chiodi A, Inglese M, Bonavita S, Clerico M, Cordioli C, Moiola L, Patti F, Lavorgna L, Filippi M, Borriello G, D'Amico E, Pozzilli C, Brescia Morra V, Lanzillo R
Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples Federico II, Via Pansini 5, Naples 810145, Italy.
Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Italy; MS Unit, Federico II University Hospital, Naples, Italy.
Mult Scler Relat Disord. 2023 Oct;78:104907. doi: 10.1016/j.msard.2023.104907. Epub 2023 Jul 26.
Although multiple sclerosis (MS) Intimacy and Sexuality Questionnaire-19 (MSISQ-19) is a widely applied tool, no unique definition of sexual dysfunction (SD) based on its score exists.
To explore the impact of different MSISQ-19 cut-offs on SD prevalence and associated risk factors, providing relevant information for its application in research and clinical settings.
After defining SD according to two different MSISQ-19 cut-offs in 1155 people with MS (pwMS), we evaluated SD prevalence and association with sociodemographic and clinical features, mood status and disability via logistic regression.
Depending on the chosen cut-off, 45% to 54% of pwMS reported SD. SD defined as MSISQ-19 score >30 was predicted by age (OR=1.01, p=0.047), cognition (OR=0.96, p=0.004) and anxiety (OR=1.03, p=0.019). SD defined as a score >3 on any MSISQ-19 item was predicted by motor disability (OR=1.12, p=0.003) and cognition (OR= 0.96, p=0.002).
Applying different MSISQ-19 cut-offs influences both the estimated prevalence and the identification of risk factors for SD, a finding that should be considered during study planning and data interpretation. Preserved cognition exerts a protective effect towards SD regardless from the specific study setting, representing a key point for the implementation of preventive and therapeutic strategies.
尽管多发性硬化症（MS）亲密关系与性问卷-19（MSISQ-19）是一种广泛应用的工具，但基于其评分尚无性功能障碍（SD）的统一明确定义。
探讨不同的MSISQ-19临界值对SD患病率及相关危险因素的影响，为其在研究和临床环境中的应用提供相关信息。
在1155例多发性硬化症患者（pwMS）中根据两种不同的MSISQ-19临界值定义SD后，我们通过逻辑回归评估SD患病率及其与社会人口统计学和临床特征、情绪状态及残疾的相关性。
根据所选临界值，45%至54%的pwMS报告有SD。年龄（OR=1.01，p=0.047）、认知功能（OR=0.96，p=0.004）和焦虑（OR=1.03，p=0.019）可预测MSISQ-19评分>30定义的SD。运动残疾（OR=1.12，p=0.003）和认知功能（OR=0.96，p=0.002）可预测MSISQ-19任何一项评分 >3定义的SD。
应用不同的MSISQ-19临界值会影响SD的估计患病率及危险因素的识别，这一发现在研究规划和数据解读过程中应予以考虑。无论具体研究背景如何，保留的认知功能对SD具有保护作用，这是实施预防和治疗策略的关键点。
