Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Rehabilitation, Rijndam Rehabilitation, Rotterdam, The Netherlands.
Neurourol Urodyn. 2018 Nov;37(8):2867-2874. doi: 10.1002/nau.23804. Epub 2018 Aug 31.
The Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15) evaluates symptoms of sexual dysfunction in patients with multiple sclerosis (MS). The objective of this study was to provide and validate a Dutch version of the MSISQ-15 in patients with neurological disease such as MS and spinal cord injury (SCI).
The linguistic validation process of the original English MSISQ-15 into Dutch was performed according to standardized guidelines. Sexually active patients with MS or spinal cord disorders, including SCI and cauda equine syndrome, who visited a tertiary urology center or a rehabilitation center completed the MSISQ-15, Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) in women, or International Index of Erection Function (IIEF-15) in men at baseline (test) and 2 weeks later (retest). A reference group recruited from a general medical practice completed the questionnaires once. Data were analyzed for measurement properties.
Fifty-three patients with MS, 49 patients with spinal cord disorder, and 50 references were included. Content validity was adequate. Internal consistency (Cronbach's alpha >0.8) and reproducibility (intraclass correlation coefficient >0.8) of the MSISQ-15 were excellent. Patients' MSISQ-15 scores were correlated with severity of symptoms of sexual dysfunction measured by PISQ-12 or IIEF-15 and confirmed positive rating for criterion validity. MSISQ-15 scores in patients were higher than in references (on a scale of 15-75: 38.9 ± 11.4 vs 21.1 ± 5.4; P < 0.001), indicating good construct validity.
The Dutch MSISQ-15 is a reliable and valid measure to evaluate symptoms of sexual dysfunction in patients with MS or with SCI.
多发性硬化症亲密关系和性生活问卷（MSISQ-15）评估多发性硬化症（MS）患者的性功能障碍症状。本研究的目的是提供并验证一种用于神经疾病患者（如 MS 和脊髓损伤（SCI））的荷兰语版 MSISQ-15。
根据标准化指南对原始英语 MSISQ-15 进行荷兰语的语言验证过程。在三级泌尿科中心或康复中心就诊的有性活动的 MS 或脊髓疾病患者，包括 SCI 和马尾综合征，在基线（测试）和 2 周后（复测）时完成 MSISQ-15、女性盆腔器官脱垂/尿失禁性功能问卷（PISQ-12）或男性国际勃起功能指数（IIEF-15）。从一般医疗实践中招募的参考组仅完成一次问卷。对数据进行测量特性分析。
共纳入 53 例 MS 患者、49 例脊髓疾病患者和 50 例参考患者。内容效度是足够的。MSISQ-15 的内部一致性（Cronbach's alpha >0.8）和可重复性（组内相关系数>0.8）都非常优秀。患者的 MSISQ-15 评分与 PISQ-12 或 IIEF-15 测量的性功能障碍症状严重程度相关，且符合标准效度的阳性评分。患者的 MSISQ-15 评分高于参考值（15-75 分的评分：38.9±11.4 与 21.1±5.4；P<0.001），表明具有良好的结构效度。
荷兰语版 MSISQ-15 是一种可靠且有效的工具，可用于评估 MS 或 SCI 患者的性功能障碍症状。
