Department of Immunology, Zunyi Medical University, Zunyi, China.
School of Pharmacy, Zunyi Medical University, Zunyi, China.
Biomed Pharmacother. 2023 Sep;165:115223. doi: 10.1016/j.biopha.2023.115223. Epub 2023 Jul 29.
Dendrobium, which belongs to the family of Orchidaceae, is a highly valuable traditional Chinese medicine commonly used in China. It exerts pharmacological activities such as antitumor and hypoglycemia effects, and its main components are alkaloids, polysaccharides, and terpenoids, among others. In recent years, research on the clinical application of Dendrobium in antitumor therapy has gained increasing attention. Accumulating evidence suggests that the active components of Dendrobium possess significant inhibitory effects on the viability of cancer cells as evident from in vivo and in vitro experiments, which indicates that Dendrobium exerts significant anticancer effect in treating and preventing cancer development, inhibiting the underlying potential molecular mechanisms, including suppression of cancer cell growth and proliferation, epithelial-mesenchymal transition (EMT), apoptosis induction, tumor angiogenesis, and reinforcement of cisplatin (DDP) -induced apoptosis. We herein present a review that summarizes the research progress of the application of Dendrobium in cancer therapy and its molecular mechanisms. This review describes the positive aspects of the active ingredients of Dendrobium in the treatment of cancers in various systems of the human body, their inhibitory effects on tumor survival and tumor microenvironment, and their potential mechanisms. Additionally, this review proposes future application prospects of Dendrobium in cancer therapy to promote further research and future extensive clinical applications of Dendrobium in cancer therapy.
石斛属兰科植物，是中国传统名贵中药材，具有抗肿瘤、降血糖等药理活性。其主要成分包括生物碱、多糖、萜类等。近年来，石斛在抗肿瘤治疗中的临床应用研究受到越来越多的关注。越来越多的证据表明，石斛中的活性成分对体内和体外实验中的癌细胞活力具有显著的抑制作用，这表明石斛在治疗和预防癌症发展方面具有显著的抗癌作用，抑制了潜在的分子机制，包括抑制癌细胞生长和增殖、上皮-间充质转化（EMT）、诱导细胞凋亡、肿瘤血管生成和增强顺铂（DDP）诱导的细胞凋亡。本文综述了石斛在癌症治疗中的应用及其分子机制的研究进展。本文描述了石斛的活性成分在治疗人体各系统癌症方面的积极作用，以及它们对肿瘤存活和肿瘤微环境的抑制作用及其潜在机制。此外，本文还提出了石斛在癌症治疗中的未来应用前景，以促进对石斛在癌症治疗中的进一步研究和未来广泛的临床应用。
