Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Pharmacology, West China School of Basic Sciences & Forensic Medicine, Animal Research Institute, Sichuan University, Chengdu, Sichuan, China.
Pharm Biol. 2020 Dec;58(1):664-673. doi: 10.1080/13880209.2020.1787470.
Kimura et Migo (Orchidaceae) is a naturally occurring precious traditional Chinese medicine (TCM) originally used in treating yin-deficiency diseases. The main active substances of are polysaccharides (DOP). Recent findings highlighted the potential of DOP as a promising natural material for medical use with a diversity of pharmaceutical effects.
In this review, we provide a systematic discussion of the current development and potential pharmacological effects of polysaccharides in dermatology.
English and Chinese literature from 1987 to 2019 indexed in databases including PubMed, PubMed Central, Web of Science, ISI, Scopus and CNKI (Chinese) was used. polysaccharides, phytochemistry, chemical constituents, biological activities, and pharmacological activities were used as the key words.
polysaccharides have been found to possess hair growth promoting, skin moisturising and antioxidant effects, which are highly valued by doctors and cosmetic engineers. We highlighted advances in moisturising and antioxidant properties from and studies. polysaccharides exhibited strong antioxidant effects by decreasing free radicals, enhancing antioxidant system, inhibiting nuclear factor-kappa B and down-regulating inflammatory response.
Our review is a foundation to inspire further research to facilitate the application of polysaccharides in dermatology and promote active research of the use of TCM in dermatology.
金粟兰（金粟兰科）是一种天然存在的珍贵中药，最初用于治疗阴虚疾病。 的主要活性物质是多糖（DOP）。最近的研究结果强调了 DOP 作为一种有前途的天然药物材料的潜力，具有多种药物作用。
本综述旨在系统讨论 多糖在皮肤科的最新发展和潜在的药理学作用。
使用了 1987 年至 2019 年期间在 PubMed、PubMed Central、Web of Science、ISI、Scopus 和中国知网（CNKI）等数据库中索引的英文和中文文献。以 多糖、植物化学、化学成分、生物活性和药理活性为关键词。
研究表明， 多糖具有促进毛发生长、保湿和抗氧化作用，深受医生和化妆品工程师的重视。我们强调了从 和 研究中获得的保湿和抗氧化特性的进展。 多糖通过减少自由基、增强抗氧化系统、抑制核因子-κB 和下调炎症反应，表现出强烈的抗氧化作用。
综上所述，本综述为进一步研究 多糖在皮肤科的应用提供了基础，并促进了中药在皮肤科应用的积极研究。
