Duchateau G S, Zuidema J, Merkus F W
Allergy. 1986 May;41(4):260-5. doi: 10.1111/j.1398-9995.1986.tb02026.x.
The in vitro and in vivo effect on the ciliary epithelial function of a new corticosteroid (budesonide), with a high topical and negligible systemic activity, was investigated. Ciliary function is an important factor in the nasal clearance mechanism. It must not be hampered by drugs or additives. Ciliary beat frequency (CBF) was measured in vitro with a photo-electric method. CBF appeared to be only slightly decreased by the budesonide and placebo aerosols. As there is no significant difference in ciliotoxicity between the aerosols, the small decrease may be caused by the solubilizing excipient. The influence of the aerosols in vivo was measured in human volunteers as changes in mucus transport time (MTT) with the indigocarmine/saccharine sodium method. Ciliotoxicity in vivo could not be found.
研究了一种新型皮质类固醇（布地奈德）对睫状上皮功能的体外和体内作用，该药物具有高局部活性且全身活性可忽略不计。睫状功能是鼻腔清除机制中的一个重要因素。它绝不能受到药物或添加剂的阻碍。采用光电法在体外测量睫状 beat 频率（CBF）。布地奈德气雾剂和安慰剂气雾剂似乎仅使 CBF 略有降低。由于气雾剂之间的纤毛毒性没有显著差异，这种小幅降低可能是由增溶辅料引起的。通过靛胭脂/糖精钠法，以黏液转运时间（MTT）的变化为指标，在人类志愿者中测量了气雾剂在体内的影响。未发现体内纤毛毒性。
