Pedersen B K, Beyer J M
Allergy. 1986 May;41(4):286-9. doi: 10.1111/j.1398-9995.1986.tb02030.x.
Natural killer (NK) cell activity against K562 target cells was studied in six patients with definite or classical rheumatoid arthritis before and during treatment with azathioprine. Azathioprine induced suppression of NK cell activity, but treatment with azathioprine for 5-8 months was necessary before NK cell activity was completely suppressed. In vitro incubation of mononuclear cells from a healthy donor with azathioprine or 6-mercaptopurine in concentrations not reducing cell viability did not inhibit NK cell activity, nor did sera from patients treated with azathioprine for more than 6 months.
在六名确诊或典型类风湿关节炎患者中，研究了在使用硫唑嘌呤治疗前及治疗期间，自然杀伤（NK）细胞对K562靶细胞的活性。硫唑嘌呤可诱导NK细胞活性受到抑制，但在NK细胞活性被完全抑制之前，需要用硫唑嘌呤治疗5至8个月。将健康供体的单核细胞与不降低细胞活力浓度的硫唑嘌呤或6-巯基嘌呤进行体外孵育，不会抑制NK细胞活性，使用硫唑嘌呤治疗超过6个月的患者血清也不会抑制NK细胞活性。
