Department of Gynecologic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
J Obstet Gynaecol Res. 2023 Oct;49(10):2528-2537. doi: 10.1111/jog.15758. Epub 2023 Jul 31.
To investigate the impact of uterine fibroid diagnosis/treatment status on quality of life (QOL) and work productivity in women living in Japan.
Women aged 20-49 years who registered on Macromill were recruited via the opt-in method. They completed an online survey on demographic and uterine fibroid diagnosis/treatment status, 36-Item Short-Form Health Survey, Uterine Fibroid Symptom and Health-Related Quality of Life questionnaire (UFS-QOL), and World Health Organization Health and Work Performance Questionnaire.
There were 4120 respondents: 1362 untreated, 249 with ongoing treatment, 449 with past treatment, 1030 with no uterine fibroids, and 1030 with unknown uterine fibroid status. A high proportion of women with ongoing treatment had moderate to severe uterine fibroid-like symptoms (symptom severity score of UFS-QOL ≥40 points), accompanied by reduced QOL. QOL was improved in women with past treatment. Uterine fibroids had a significant impact on physical and psychosocial aspects in the ongoing treatment group versus other groups. Using classification and regression tree analysis, anemia was identified as a plausible predictor of reduced QOL in the ongoing treatment group. Approximately 20% of women-even in groups other than the ongoing treatment group-experienced moderate to severe uterine fibroid-like symptoms. However, the diagnosis and treatment status of uterine fibroids had no clear impact on work productivity.
Uterine fibroids, especially in association with anemia, were related to reduced QOL. Given that uterine fibroid-related reduced QOL is likely improved by appropriate treatment, women with uterine fibroid-like symptoms, such as menorrhagia, should be examined and treated.
调查子宫肌瘤的诊断/治疗状况对日本女性生活质量（QOL）和工作生产力的影响。
通过参与式方法，招募年龄在 20-49 岁之间在 Macromill 注册的女性。她们在线完成了关于人口统计学和子宫肌瘤诊断/治疗状况、36 项简短健康调查、子宫肌瘤症状和健康相关生活质量问卷（UFS-QOL）以及世界卫生组织健康和工作绩效问卷的调查。
共有 4120 名受访者：1362 名未治疗、249 名正在治疗、449 名既往治疗、1030 名无子宫肌瘤和 1030 名子宫肌瘤状况未知。正在治疗的女性中有很大一部分患有中度至重度子宫肌瘤样症状（UFS-QOL 症状严重程度评分≥40 分），伴随 QOL 降低。既往治疗的女性 QOL 得到改善。子宫肌瘤对正在治疗组的生理和心理社会方面有显著影响，而其他组则没有。使用分类回归树分析，贫血被确定为正在治疗组 QOL 降低的一个合理预测因素。约 20%的女性——即使在除正在治疗组以外的组——都经历了中度至重度的子宫肌瘤样症状。然而，子宫肌瘤的诊断和治疗状况对工作生产力没有明显影响。
子宫肌瘤，特别是伴有贫血的子宫肌瘤，与 QOL 降低有关。鉴于适当的治疗可能改善与子宫肌瘤相关的 QOL 降低，因此对于出现月经过多等子宫肌瘤样症状的女性，应进行检查和治疗。
