Dou J R, Zhou X, Pan X Y, Miao R F, Zhou M L, Zhang F
Occupational Health Department of Yangzhou Center for Disease Control and Prevention, Yangzhou 225001, China.
Emergency Department of Affiliated Hospital of Yangzhou University, Yangzhou 225009, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2023 Jul 20;41(7):517-522. doi: 10.3760/cma.j.cn121094-20220329-00162.
To analyze the concentrations of glyphosate and its metabolites in occupational exposed workers and their possible effects on human health, so as to provide a reference for improving the safe use of glyphosate and toxicity research. From April to December 2020, 247 workers directly exposed to glyphosate in 5 enterprises were selected as the contact group, and 237 workers who were not exposed to glyphosate and other pesticides in the same enterprise were selected as the control group. Questionnaire survey and occupational health examination were conducted on objects, and the concentrations of glyphosate and its metabolites in the air of workplaces and biological samples were detected. The correlation between the concentrations and the difference of health examination between the two groups were analyzed. The urine glyphosate concentration (0.022-47.668 mg/L), the rate of exceeding the standard (60.32%, 149/247) and the urine aminomethyl phosphonic acid concentration (<0.010-1.624 mg/L) in the contact group were higher than those in the control group [urine glyphosate concentration (<0.020-4.482 mg/L), the rate of exceeding the standard (2.53%, 6/237) and the urine aminomethyl phosphonic acid concentration (<0.010-0.524 mg/L) ], respectively (<0.001). The exceeding standard rate of glyphosate concentration in the workplace was 33.67% (33/98). The concentration of glyphosate in the workplace was positively correlated with the concentrations of glyphosate and aminomethylphosphonic acid in urine ((s)=0.804, 0.238, <0.001), and the concentration of glyphosate in urine was positively correlated with the concentration of aminomethylphosphonic acid in urine ((s)=0.549, <0.001). The alanine aminotransferase (ALT), white cell ratio, creatinine, uric acid, the abnormal rates of ALT and total protein (TP) in the contact group were higher than those in the control group, and TP was lower than that in the control group, the differences were statistically different (<0.05). The abnormal rates of overall liver function, overall renal function, blood routine test, urine routine test, electrocardiogram, liver B ultrasound and blood lipid in the contact group were significantly higher than those in the control group (<0.05) . The concentration of glyphosate in the workplace is related to the concentrations of glyphosate and aminomethyl phosphonic acid in the urine of workers, and exposure to glyphosate may have some harmful effects on human health.
分析职业暴露工人中草甘膦及其代谢物的浓度及其对人体健康的可能影响，为提高草甘膦安全使用水平及毒性研究提供参考。选取2020年4月至12月5家企业中直接接触草甘膦的247名工人作为接触组，选取同企业中未接触草甘膦及其他农药的237名工人作为对照组。对研究对象进行问卷调查和职业健康检查，并检测工作场所空气中草甘膦及其代谢物浓度和生物样本。分析两组浓度与健康检查差异之间的相关性。接触组尿中草甘膦浓度（0.022～47.668mg/L）、超标率（60.32%，149/247）及尿中氨甲基膦酸浓度（<0.010～1.624mg/L）均高于对照组[尿中草甘膦浓度（<0.020～4.482mg/L）、超标率（2.53%，6/237）及尿中氨甲基膦酸浓度（<0.010～0.524mg/L）]，差异均有统计学意义（<0.001）。工作场所草甘膦浓度超标率为33.67%（33/98）。工作场所草甘膦浓度与尿中草甘膦及氨甲基膦酸浓度呈正相关（r=0.804、0.238，<0.001），尿中草甘膦浓度与尿中氨甲基膦酸浓度呈正相关（r=0.549，<0.0
