Zhang F, Pan L P, Ding E M, Ge Q J, Zhang Z H, Xu J N, Zhang L, Zhu B L
Department of Occupational Health, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2017 Jul 6;51(7):615-620. doi: 10.3760/cma.j.issn.0253-9624.2017.07.008.
To explore the effect of occupational exposure to glyphosate on hepatorenal function. 526 workers who were occupationally exposed to glyphosate from 5 glyphosate-producing factories were selected as cases; and another 442 administrative staffs who were not exposed to glyphosate were selected as controls from April to November, 2014. All the subjects accepted occupational health examination. The concentration level of glyphosate in the air of workshop was detected and the time weighted average concentration (TWA) was calculated. And analyze the difference of hepatorenal fuction between case group and control group. The age of the subjects in the case and control groups were separately (35.6±10.3), (34.3±9.7) years old, with the length of working for (6.5±5.7), (7.7±6.8) years. The TWA of glyphosate in the case group was between <0.03-48.91 mg/m(3), with the geometric mean at 3.78 mg/m(3). The overall rates of abnormal hepatic and renal function in the case group were 14.4% (76 cases) and 16.2% (85 cases), respectively; while those were 5.0% (22 cases) and 4.8% (21 cases), respectively in control group, and the difference showed statistical significance (<0.05). When TWA reached <0.03-6.00 mg/m(3), the difference of hepatorenal fuction between case group and control group showed statistical significance, and the rates of abnormal hepatic and renal function was 8.0% (36/447) and 9.8% (44/447) respectively in case group. When cumulative exposure level reached <1.56-68.64 g, the difference of hepatorenal fuction between case group and control group showed statistical significance, and the rates increased to 9.2% (37/404) and 10.4% (42/404) respectively in group of cases. Glyphosate can affect the hepatic and renal function among occupational exposure population, and there was an association between the effect and the exposure dose.
为探讨职业接触草甘膦对肝肾功能的影响。选取5家草甘膦生产厂职业接触草甘膦的526名工人作为病例组；于2014年4月至11月选取442名未接触草甘膦的行政人员作为对照组。所有研究对象均接受职业健康检查。检测车间空气中草甘膦浓度水平并计算时间加权平均浓度（TWA）。分析病例组与对照组肝肾功能的差异。病例组与对照组研究对象年龄分别为（35.6±10.3）、（34.3±9.7）岁，工龄分别为（6.5±5.7）、（7.7±6.8）年。病例组草甘膦TWA为<0.03 - 48.91mg/m³，几何均值为3.78mg/m³。病例组肝功能和肾功能异常总发生率分别为14.4%（76例）和16.2%（85例）；对照组分别为5.0%（22例）和4.8%（21例），差异有统计学意义（<0.05）。当TWA为<0.03 - 6.00mg/m³时，病例组与对照组肝肾功能差异有统计学意义，病例组肝功能和肾功能异常发生率分别为8.0%（36/447）和9.8%（44/447）。当累积暴露量为<1.56 - 68.64g时，病例组与对照组肝肾功能差异有统计学意义，病例组发生率分别增至9.2%（37/404）和10.4%（42/404）。草甘膦可影响职业接触人群的肝肾功能，且该影响与暴露剂量有关。
