Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Sci Rep. 2023 Jul 31;13(1):12336. doi: 10.1038/s41598-023-39461-3.
Thailand is known to be endemic for leptospirosis. This bacterium may pose a potential risk to transfusion safety. This study was a cross-sectional study examining the seroprevalence of leptospirosis among Thai blood donors. A total of 1053 serum specimens collected from blood donors residing in 5 regions of Thailand during March to September 2020 were included in this study. All samples were tested for the presence of antibodies to 22 leptospiral serovars using the microscopic agglutination test (MAT) and anti-Leptospira IgG antibodies using commercially available enzyme immunoassay. We found no evidence of recent exposure to Leptospira spp. in sera of healthy Thai blood donors by MAT, including those in higher-risk areas. However, in this same group, we did find small numbers of past exposure (1.7%) to Leptospira spp. by IgG ELISA. According to the findings of this study, there is currently no evidence for implementing new blood banking procedures to identify possible carriers in Thailand, however these should be continually monitored and revised according to the infectious disease burden in each country. It should be noted that there was a difference in the occupation rate between the general population reported in Thailand and blood donors in this study; it may not reflect the actual situation in the country.
泰国被认为是地方性流行钩端螺旋体病的地区。这种细菌可能对输血安全构成潜在风险。本研究是一项横断面研究，旨在检查泰国献血者中钩端螺旋体病的血清流行率。共纳入了 2020 年 3 月至 9 月期间来自泰国 5 个地区的 1053 份献血者血清标本。所有样本均采用显微镜凝集试验（MAT）和商业酶联免疫吸附试验（ELISA）检测 22 种钩端螺旋体血清型的抗体。我们通过 MAT 未发现健康泰国献血者血清中有近期接触钩端螺旋体的证据，包括来自高风险地区的献血者。然而，在同一组中，我们确实通过 IgG ELISA 发现了少量过去接触（1.7%）钩端螺旋体的证据。根据本研究的结果，目前没有证据表明需要在泰国实施新的血库程序来识别可能的携带者，但应根据每个国家的传染病负担持续监测和修订这些程序。需要注意的是，本研究中报告的泰国一般人群和献血者的职业率存在差异；这可能无法反映该国的实际情况。
