潜在有机氟抗菌剂的研究。第2部分：一些新型含氟3,5-二取代异恶唑的合成与抗菌活性
Studies in potential organo-fluorine antibacterial agents. Part 2: Synthesis and antibacterial activity of some new fluorine-containing 3.5-disubstituted isoxazoles.
作者信息
Joshi K C, Pathak V N, Grover V
出版信息
Pharmazie. 1979;34(2):68-9.
PMID:375248
Abstract
A series of new fluorine-containing 3,5-disubstituted aryl/alkylisoxazoles has been synthesized by the condensation of hydroxylamine with appropriate beta-diketones in the presence of pyridine and characterized by IR and 1H NMR spectral studies. These isoxazoles have been screened for their antibacterial activity against the gram positive bacteria, Staphylococcus albus, Streptococcus nonhemolyticus and the gram negative bacterium Escherichia coli.
摘要
通过在吡啶存在下使羟胺与适当的β-二酮缩合，合成了一系列新的含氟3,5-二取代芳基/烷基异恶唑，并通过红外光谱和1H核磁共振光谱研究对其进行了表征。已对这些异恶唑针对革兰氏阳性菌白葡萄球菌、非溶血性链球菌以及革兰氏阴性菌大肠杆菌的抗菌活性进行了筛选。
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