Department of Genetics and Biotechnology, Kyung Hee University, Yongin, 1732, Korea.
Research and Development Center, Skin Biotechnology Center Co., Ltd, Yongin, 17104, Korea.
Microbiol Immunol. 2023 Oct;67(10):456-467. doi: 10.1111/1348-0421.13093. Epub 2023 Jul 31.
Defensins and inflammation are innate immune barriers of the body against infectious pathogens. Searching for a compound that can inhibit infectious diseases by affecting human β-defensin (HBD) and proinflammatory cytokines is the new trend in research to control bacterial infection. The aim of this study is to provide a natural compound, Filipendula glaberrima Nakai extract (FGE), which is able to induce the expression of an antimicrobial defensin as well as reduce inflammation. FGE induced the expression of HBD2 and HBD3 through activating both p38 and NF-κB signaling pathways. Furthermore, FGE inhibited the expression of TNF-α and IL-6 via p38 and NF-κB pathways in Staphylococcus aureus-stimulated THP1 cells. Injection of FGE alleviated cutaneous erythema and swelling caused by S. aureus injection in mice ears. Taken together, FGE could reduce bacterial infection by inducing the expression of defensin and anti-inflammatory activity.
防御素和炎症是人体针对感染性病原体的先天免疫屏障。寻找一种通过影响人β-防御素（HBD）和促炎细胞因子来抑制传染病的化合物，是控制细菌感染研究的新趋势。本研究旨在提供一种天然化合物，掌叶覆盆子提取物（FGE），它能够诱导抗菌防御素的表达并减轻炎症。FGE 通过激活 p38 和 NF-κB 信号通路诱导 HBD2 和 HBD3 的表达。此外，FGE 通过 p38 和 NF-κB 通路抑制金黄色葡萄球菌刺激的 THP1 细胞中 TNF-α 和 IL-6 的表达。FGE 的注射减轻了金黄色葡萄球菌注射引起的小鼠耳部皮肤红斑和肿胀。总之，FGE 可以通过诱导防御素的表达和抗炎活性来减少细菌感染。
