Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.
Interdisciplinary Research Unit, National Institute for Basic Biology, Okazaki, Japan.
Mol Microbiol. 2023 Nov;120(5):645-657. doi: 10.1111/mmi.15134. Epub 2023 Jul 31.
In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary phase, termed the chronological lifespan (CLS), is affected by various environmental factors and the corresponding gene activities. The ecl family genes were identified in the genomic region encoding non-coding RNA as positive regulators of CLS in S. pombe, and subsequently shown to encode relatively short proteins. Several studies revealed that ecl family genes respond to various nutritional starvation conditions via different mechanisms, and they are additionally involved in stress resistance, autophagy, sexual differentiation, and cell cycle control. Recent studies reported that Ecl family proteins strongly suppress target of rapamycin complex 1, which is a conserved eukaryotic nutrient-sensing kinase complex that also regulates longevity in a variety of organisms. In this review, we introduce the regulatory mechanisms of Ecl family proteins and discuss their emerging findings.
在裂殖酵母 Schizosaccharomyces pombe 中，其在静止期的存活时间，即所谓的时序寿命 (CLS)，会受到各种环境因素和相应基因活性的影响。ecl 家族基因在编码非编码 RNA 的基因组区域被鉴定为 CLS 的正调控因子，随后被证明编码相对较短的蛋白质。多项研究表明，ecl 家族基因通过不同的机制对各种营养饥饿条件做出响应，它们还参与应激反应、自噬、性分化和细胞周期控制。最近的研究报告称，Ecl 家族蛋白强烈抑制雷帕霉素靶蛋白复合物 1（mTORC1），mTORC1 是一种保守的真核营养感应激酶复合物，它也调节多种生物的寿命。在这篇综述中，我们介绍了 Ecl 家族蛋白的调节机制，并讨论了它们的新发现。
