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[在阿尔方斯·拉韦朗之后]

[In the wake of Alphonse Laveran].

作者信息

Berche Patrick

机构信息

Professeur émérite, Université Paris Cité, 85 boulevard Saint-Germain 75006, Paris, France.

* Actes du Colloque - Centenaire de la mort d'Alphonse Laveran. 24 novembre 2022, Paris / Proceedings of the Conference - Centenary of the death of Alphonse Laveran. 24 November 2022, Paris.

出版信息

Med Trop Sante Int. 2023 Apr 25;3(2). doi: 10.48327/mtsi.v3i2.2023.331. eCollection 2023 Jun 30.

Abstract

Alphonse Laveran (Nobel Prize 1907) played a pioneering role in discovering the causative agent of malaria, a disease that has existed since time immemorial, and long emblematic of the miasma theory until the end of the 19 century. In 1880, this unknown military doctor discovered the role of a hematazoan in malaria, designated This was the first protozoan to be discovered in an infectious disease, at a time when bacteria were mainly suspected. This major discovery led to the identification of the role of mosquitoes in the spread of malaria by Ronald Ross (Nobel Prize 1902) and Battista Grassi. The recurrence of malaria attacks over many years was for a long time an enigma only solved after the Second World War by the discovery of the exo-erythrocytic cycle of Progress was then made in treatment, from cinchona bark, quinine and chloroquine, to the recent discovery of artemisinin in 1972 by the Chinese researcher Tu Youyou (Nobel Prize 2015).

摘要

阿尔方斯·拉韦朗(1907年诺贝尔奖获得者)在发现疟疾病原体方面发挥了开创性作用。疟疾是一种自古以来就存在的疾病,在19世纪末之前一直是瘴气理论的典型代表。1880年,这位籍籍无名的军医发现了一种血内寄生虫在疟疾中的作用,命名为 这是在传染病中发现的第一种原生动物,当时人们主要怀疑是细菌致病。这一重大发现促使罗纳德·罗斯(1902年诺贝尔奖获得者)和巴蒂斯塔·格拉西确定了蚊子在疟疾传播中的作用。多年来疟疾发作的反复出现长期以来一直是个谜,直到第二次世界大战后发现了 才得以解决。随后在治疗方面取得了进展,从金鸡纳树皮、奎宁和氯喹,到中国研究人员屠呦呦在1972年发现青蒿素(2015年诺贝尔奖)。

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本文引用的文献

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Artemisinin: discovery from the Chinese herbal garden.青蒿素:源自中草药园的发现。
Cell. 2011 Sep 16;146(6):855-8. doi: 10.1016/j.cell.2011.08.024. Epub 2011 Sep 9.
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The history of the malaria treatment of general paralysis.
Am J Psychiatry. 1946 Mar;102:577-82. doi: 10.1176/ajp.102.5.577.
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ON THE HAEMATOZOAN INFECTIONS OF BIRDS.论鸟类的血寄生虫感染
J Exp Med. 1898 Jan 1;3(1):117-36. doi: 10.1084/jem.3.1.117.

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