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The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine.

作者信息

Tu Youyou

机构信息

Qinghaosu Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

出版信息

Nat Med. 2011 Oct 11;17(10):1217-20. doi: 10.1038/nm.2471.

DOI:10.1038/nm.2471
PMID:21989013
Abstract
摘要

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The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine.青蒿素（青蒿琥酯）的发现与来自中医药的馈赠。
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Investigation of the component in Artemisia annua L. leading to enhanced antiplasmodial potency of artemisinin via regulation of its metabolism.青蒿素代谢调控增强青蒿素抗疟活性的成分研究。
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Clin Hemorheol Microcirc. 2011;47(3):187-98. doi: 10.3233/CH-2010-1380.
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Cerebralcare Granule, a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion.脑心舒颗粒改善缺血再灌注沙土鼠脑微循环障碍及海马 CA1 区神经元损伤
J Ethnopharmacol. 2010 Jul 20;130(2):398-406. doi: 10.1016/j.jep.2010.05.030. Epub 2010 May 24.
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The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells.
采用非靶向代谢组学方法比较黄花蒿茶的成分及抗疟活性。
PLoS One. 2025 Aug 22;20(8):e0330682. doi: 10.1371/journal.pone.0330682. eCollection 2025.
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Inhibitory effects of berberine against : an insight on its anticaries potential.黄连素的抑制作用：对其防龋潜力的见解
Microbiol Spectr. 2025 Aug 12:e0070025. doi: 10.1128/spectrum.00700-25.
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Inhibitory effects of herbal monomers on ferroptosis in renal fibrosis: a review and mechanistic study.草药单体对肾纤维化中铁死亡的抑制作用：综述与机制研究
Front Pharmacol. 2025 Jul 22;16:1610573. doi: 10.3389/fphar.2025.1610573. eCollection 2025.
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Artemisiae Annuae Herba: from anti-malarial legacy to emerging anti-cancer potential.青蒿：从抗疟传统到新出现的抗癌潜力
Theranostics. 2025 Jun 20;15(15):7346-7377. doi: 10.7150/thno.115414. eCollection 2025.
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The molecular mechanism of ambrosin-induced cytotoxicity of human breast cancer and bladder cancer cells.蛇床子素诱导人乳腺癌和膀胱癌细胞毒性的分子机制。
J Biol Chem. 2025 Aug 5;301(9):110531. doi: 10.1016/j.jbc.2025.110531.
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Value Addition to African Natural Product-Based Drug Discovery Initiatives.为基于非洲天然产物的药物发现计划增添价值。
J Nat Prod. 2025 Aug 22;88(8):2018-2028. doi: 10.1021/acs.jnatprod.5c00446. Epub 2025 Jul 29.
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Genome-Wide Analysis of Oxidosqualene Cyclase Genes in : Evolution, Expression, and Potential Roles in Triterpenoid Biosynthesis.[物种名称]中氧化角鲨烯环化酶基因的全基因组分析：进化、表达及在三萜生物合成中的潜在作用
Curr Issues Mol Biol. 2025 Jul 14;47(7):545. doi: 10.3390/cimb47070545.
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Biosynthesis and bioactivity of anti-inflammatory triterpenoids in Calendula officinalis.金盏花中抗炎三萜类化合物的生物合成与生物活性
Nat Commun. 2025 Jul 28;16(1):6941. doi: 10.1038/s41467-025-62269-w.
丹酚酸 B 联合切应力对 TNF-α 刺激人主动脉内皮细胞黏附分子表达的影响。
Clin Hemorheol Microcirc. 2010;44(4):245-58. doi: 10.3233/CH-2010-1269.
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Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.三氧化二砷通过直接结合 PML 来控制 PML-RARα 癌蛋白的命运。
Science. 2010 Apr 9;328(5975):240-3. doi: 10.1126/science.1183424.
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The effect of Xuefu Zhuyu Decoction on in vitro endothelial progenitor cell tube formation.血府逐瘀汤对体外血管内皮祖细胞管腔形成的影响。
Chin J Integr Med. 2010 Feb;16(1):50-3. doi: 10.1007/s11655-010-0050-y. Epub 2010 Feb 4.
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Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats.强心丸，一种复方中药，可保护大鼠缺血再灌注引起的微循环障碍和心肌损伤。
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The antioxidant Cerebralcare Granule attenuates cerebral microcirculatory disturbance during ischemia-reperfusion injury.抗氧化剂脑心健颗粒可减轻缺血再灌注损伤期间的脑微循环障碍。
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Yao Xue Xue Bao. 2007 Sep;42(9):978-81.
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Pharmacol Ther. 2008 Feb;117(2):280-95. doi: 10.1016/j.pharmthera.2007.09.008. Epub 2007 Oct 16.
10
Creation and revelation: two different routes to advancement in the biomedical sciences.创新与发现：生物医学科学进步的两条不同路径。
Nat Med. 2007 Oct;13(10):1151-4. doi: 10.1038/nm1642.