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1例哌替啶静脉注射后皮肤坏死病例。

A case of skin necrosis following pethidine intravenous injection.

作者信息

AlQhtani Abdullh

机构信息

Plastic Surgery, Surgery Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al Kharj 16273-7201, Saudi Arabia.

出版信息

J Surg Case Rep. 2023 Jul 29;2023(7):rjad431. doi: 10.1093/jscr/rjad431. eCollection 2023 Jul.

DOI:10.1093/jscr/rjad431
PMID:37525753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10387366/
Abstract

Pethidine is an opioid derivative typically used to treat moderate-to-severe pain. It has a good analgesic effect and is considered safe, although with adverse effects such as nausea, depression, vomiting, respiratory depression, and toxicity. We discuss the case of a 43-year-old female patient who received intravenous pethidine and developed skin necrosis in multiple areas of the body as a complication and how it was managed. This is the first report in the literature discussing skin necrosis after intravenous pethidine.

摘要

哌替啶是一种阿片类衍生物，通常用于治疗中重度疼痛。它具有良好的镇痛效果，且被认为是安全的，尽管存在恶心、抑郁、呕吐、呼吸抑制和毒性等不良反应。我们讨论了一名43岁女性患者的病例，该患者接受静脉注射哌替啶后出现身体多个部位皮肤坏死这一并发症以及如何对其进行处理。这是文献中首例讨论静脉注射哌替啶后发生皮肤坏死的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab2/10387366/5f32855cfd84/rjad431f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab2/10387366/abd6cb099c01/rjad431f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab2/10387366/bb9365fae5f4/rjad431f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab2/10387366/5f32855cfd84/rjad431f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab2/10387366/abd6cb099c01/rjad431f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab2/10387366/bb9365fae5f4/rjad431f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab2/10387366/5f32855cfd84/rjad431f3.jpg

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A case of skin necrosis following pethidine intravenous injection.1例哌替啶静脉注射后皮肤坏死病例。
J Surg Case Rep. 2023 Jul 29;2023(7):rjad431. doi: 10.1093/jscr/rjad431. eCollection 2023 Jul.
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本文引用的文献

1
Warfarin-induced major unilateral breast necrosis in a patient with antiphospholipid syndrome: A case report.华法林致抗磷脂综合征患者单侧乳腺大面积坏死：一例报告
Int J Surg Case Rep. 2020;77:656-659. doi: 10.1016/j.ijscr.2020.11.111. Epub 2020 Nov 23.
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Pethidine in labour; results in 500 cases.分娩时使用哌替啶；500例病例的结果
Br Med J. 1947 Apr 5;1(4500):437-42. doi: 10.1136/bmj.1.4500.437.
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Side effects of opioids during short-term administration: effect of age, gender, and race.阿片类药物短期使用期间的副作用：年龄、性别和种族的影响。
Clin Pharmacol Ther. 2003 Aug;74(2):102-12. doi: 10.1016/S0009-9236(03)00152-8.
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Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study.重症多形红斑、史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的临床模式与病因之间的相关性：一项国际前瞻性研究的结果
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Management of extravasation injuries.外渗性损伤的处理
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Dose requirements, efficacy and side effects of morphine and pethidine delivered by patient-controlled analgesia after gynaecological surgery.妇科手术后患者自控镇痛使用吗啡和哌替啶的剂量需求、疗效及副作用
Br J Anaesth. 1996 Apr;76(4):484-6. doi: 10.1093/bja/76.4.484.
7
What syndrome is this? Nicolau syndrome.这是什么综合征？尼科劳综合征。
Pediatr Dermatol. 1995 Jun;12(2):187-90. doi: 10.1111/j.1525-1470.1995.tb00151.x.
8
Central nervous system excitatory effects of meperidine in cancer patients.
Ann Neurol. 1983 Feb;13(2):180-5. doi: 10.1002/ana.410130213.
9
Side effects of morphine patient-controlled analgesia and meperidine patient-controlled analgesia: a follow-up of 500 patients.
AANA J. 1992 Jun;60(3):282-6.