Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
J Agric Food Chem. 2023 Aug 23;71(33):12574-12586. doi: 10.1021/acs.jafc.3c02934. Epub 2023 Aug 1.
Subacute mycotoxin exposure in food is commonly overlooked. As one of the most toxic trichothecene mycotoxins, the T-2 toxin severely pollutes human foods and animal feeds. In our study, we investigated the effects of low-dose T-2 toxin on glucose and lipid metabolic function and further investigated the protective effect of tannic acid (TA) in C57BL/6J mice. Results showed that low-dose T-2 toxin significantly impaired blood glucose and lipid homeostasis, promoted ferroptosis in the pancreas and subsequent repression of insulin secretion in β-cells, and impacted hepatic glucose and lipid metabolism by targeted inhibition of the insulin receptor substrate (IRS)/phosphatidylin-ositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, which induced insulin resistance and steatosis in the liver. TA treatment attenuated pancreatic function and hepatic metabolism by ameliorating oxidative stress and insulin resistance in mice. These findings provide new perspectives on the toxic mechanism and intervention of chronic subacute toxicity of foodborne mycotoxins.
食物中的亚急性霉菌毒素暴露通常被忽视。T-2 毒素作为最具毒性的单端孢霉烯族霉菌毒素之一，严重污染人类食品和动物饲料。在我们的研究中，我们调查了低剂量 T-2 毒素对葡萄糖和脂质代谢功能的影响，并进一步研究了没食子酸（TA）在 C57BL/6J 小鼠中的保护作用。结果表明，低剂量 T-2 毒素显著损害血糖和脂质稳态，促进胰腺中的铁死亡，随后抑制β细胞中的胰岛素分泌，并通过靶向抑制胰岛素受体底物（IRS）/磷酸肌醇-3-激酶（PI3K）/蛋白激酶 B（AKT）信号通路影响肝葡萄糖和脂质代谢，导致肝胰岛素抵抗和脂肪变性。TA 处理通过改善氧化应激和小鼠的胰岛素抵抗来减轻胰腺功能和肝脏代谢。这些发现为食源性病原体慢性亚急性毒性的毒性机制和干预提供了新的视角。
