Department of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan.
Institute for Research Excellence in Learning Science, National Taiwan Normal University, Taipei, Taiwan.
J Gerontol A Biol Sci Med Sci. 2024 Feb 1;79(2). doi: 10.1093/gerona/glad179.
Acute exercise is a behavior that benefits cognitive function; however, its effect on populations with different risks for Alzheimer's disease (AD) and the role of exercise variance and Apolipoprotein E (APOE) genotype on this effect remains unknown. This study explores the acute exercise effect on behavioral and neurocognitive function, and its potential moderation by exercise intensity and duration and APOE genetic risk.
Fifty-one cognitively normal adults (~36% APOE ε4 carriers) performed the Stroop task under a rest condition and 3 exercise conditions while electroencephalographic activity was assessed.
Acute exercise improved cognitive performance assessed through both behavioral and neuroelectrical indices. These benefits were observed regardless of adjustments of intensity and duration at a predetermined exercise volume as well as being evident irrespective of APOE ɛ4 carrier status.
Acute exercise could be proposed as a lifestyle intervention to benefit neurocognitive function in populations with and without genetic risk of AD. Future exploration should further the precise exercise prescription and also the mechanisms underlying the beneficial effects of acute exercise for neurocognitive function.
NCT05591313.
急性运动对认知功能有益；然而，其对具有不同阿尔茨海默病（AD）风险人群的影响以及运动变化和载脂蛋白 E（APOE）基因型在该影响中的作用尚不清楚。本研究探讨了急性运动对行为和神经认知功能的影响，以及其是否可通过运动强度和持续时间以及 APOE 遗传风险来调节。
51 名认知正常的成年人（~36%APOE ε4 携带者）在静息状态和 3 种运动状态下进行 Stroop 任务，同时评估脑电图活动。
急性运动改善了通过行为和神经电指标评估的认知表现。这些益处无论在预定运动量下调整强度和持续时间与否，以及无论 APOE ɛ4 携带状态如何，均能观察到。
急性运动可作为一种生活方式干预措施，为具有和不具有 AD 遗传风险的人群提供神经认知功能益处。未来的探索应进一步确定精确的运动处方，并阐明急性运动对神经认知功能有益影响的机制。
NCT05591313。
