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Multiomics and Multiancestry Approaches: Key Steps to Untangling the Web of Chronic Obstructive Pulmonary Disease Pathogenesis.

作者信息

Radder Josiah E, Bon Jessica

机构信息

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

出版信息

Ann Am Thorac Soc. 2023 Aug;20(8):1101-1102. doi: 10.1513/AnnalsATS.202304-311ED.

DOI:10.1513/AnnalsATS.202304-311ED
PMID:37526482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10405612/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1746/10405612/d995ce2fdeba/AnnalsATS.202304-311EDUf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1746/10405612/d995ce2fdeba/AnnalsATS.202304-311EDUf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1746/10405612/d995ce2fdeba/AnnalsATS.202304-311EDUf1.jpg

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本文引用的文献

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Ann Am Thorac Soc. 2023 Aug;20(8):1124-1135. doi: 10.1513/AnnalsATS.202210-857OC.
2
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.多祖裔全基因组关联分析提高了影响肺功能和慢性阻塞性肺疾病风险的基因和通路的分辨率。
Nat Genet. 2023 Mar;55(3):410-422. doi: 10.1038/s41588-023-01314-0. Epub 2023 Mar 13.
3
Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program.
关于种族、族裔和血统在基因研究中的使用及报告的建议：美国国立心、肺、血液研究所（NHLBI）精准医学跨组学研究项目（TOPMed）的经验
Cell Genom. 2022 Aug 10;2(8). doi: 10.1016/j.xgen.2022.100155. Epub 2022 Jul 26.
4
Adopting a "Compound" Exposome Approach in Environmental Aging Biomarker Research: A Call to Action for Advancing Racial Health Equity.采用“复合”外显子组方法进行环境老化生物标志物研究：推进种族健康公平的行动呼吁。
Environ Health Perspect. 2021 Apr;129(4):45001. doi: 10.1289/EHP8392. Epub 2021 Apr 6.
5
Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.全基因组关联研究确定了与不同局部柱状肺气肿模式相关的调控位点。
Am J Respir Crit Care Med. 2014 Aug 15;190(4):399-409. doi: 10.1164/rccm.201403-0569OC.
6
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.慢性阻塞性肺疾病风险基因座的全基因组关联研究和荟萃分析。
Lancet Respir Med. 2014 Mar;2(3):214-25. doi: 10.1016/S2213-2600(14)70002-5. Epub 2014 Feb 7.
7
Variants in FAM13A are associated with chronic obstructive pulmonary disease.FAM13A 中的变异与慢性阻塞性肺疾病有关。
Nat Genet. 2010 Mar;42(3):200-2. doi: 10.1038/ng.535. Epub 2010 Feb 21.
8
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.一项慢性阻塞性肺疾病（COPD）的全基因组关联研究：两个主要易感基因座的鉴定。
PLoS Genet. 2009 Mar;5(3):e1000421. doi: 10.1371/journal.pgen.1000421. Epub 2009 Mar 20.