Øverberg Linda Thøring, Lugg Elise Fritsch, Gaarder Mona, Langhammer Birgitta, Thommessen Bente, Rønning Ole Morten, Morland Cecilie
Department of Behavioral Sciences, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Oslo, Norway.
Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, The Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Heliyon. 2022 Jun 10;8(6):e09661. doi: 10.1016/j.heliyon.2022.e09661. eCollection 2022 Jun.
Stroke affects almost 14 million people worldwide each year. It is the second leading cause of death and a major cause of acquired disability. The degree of initial impairment in cognitive and motor functions greatly affects the recovery, but idiosyncratic factors also contribute. These are largely unidentified, which contributes to making accurate prediction of recovery challenging. Release of soluble regulators of neurotoxicity, neuroprotection and repair are presumably essential. Here we measured plasma levels of known regulators of neuroprotection and repair in patients with mild acute ischemic stroke and compared them to the plasma levels in healthy age and gender matched controls. We found that the levels of BDNF and EGF were substantially lower in stroke patients than in healthy controls, while the levels of bFGF and irisin did not differ between the groups. The lower levels of growth factors highlight that during the acute phase of stroke, there is a mismatch between the need for neuroprotection and repair, and the brain's ability to induce these processes. Large individual differences in growth factor levels were seen among the stroke patients, but whether these can be used as predictors of long-term prognosis remains to be investigated.
每年全球有近1400万人受到中风影响。中风是第二大致死原因，也是后天残疾的主要原因。认知和运动功能的初始损伤程度对恢复有很大影响，但个体因素也起作用。这些因素大多未被识别，这使得准确预测恢复情况具有挑战性。释放神经毒性、神经保护和修复的可溶性调节因子可能至关重要。在此，我们测量了轻度急性缺血性中风患者血浆中已知的神经保护和修复调节因子水平，并将其与年龄和性别匹配的健康对照者的血浆水平进行比较。我们发现，中风患者的BDNF和EGF水平显著低于健康对照者，而bFGF和鸢尾素水平在两组之间没有差异。生长因子水平较低表明，在中风急性期，神经保护和修复的需求与大脑诱导这些过程的能力之间存在不匹配。中风患者中生长因子水平存在很大的个体差异，但这些差异是否可用于预测长期预后仍有待研究。
