Nephrology Division, Department of Internal Medicine, School of Medicine, University of Jordan, Amman, Jordan.
School of Medicine, University of Jordan Hospital, Amman, Jordan.
Ann Med. 2023;55(2):2242248. doi: 10.1080/07853890.2023.2242248.
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly utilized to reduce pain, inflammation, and fever. This study aimed to assess patterns of use and awareness of NSAID-related side-effects in an adult Jordanian. And the associations with sociodemographic factors. This cross-sectional study among a representative sample of 604 adults >18 years. A validated, self-administered questionnaire was used to collect basic sociodemographic data from the participants, as well as information regarding NSAID use. Most respondents were NSAID users (65.7%), female (53.4%) and under 50 years of age (74.5%). Overall, 42.6% had been prescribed NSAIDs by a physician. Male gender and smoking were negatively correlated with NSAIDs use (multivariable odds ratio [OR]: 0.5, 95% confidence interval [CI]: 0.4-0.8, = 0.001 and OR: 0.6, 95% CI 0.4-0.8, = 0.003). In contrast, the Ministry of Health Insurance was associated with NSAIDs use with OR: 1.6, 95% CI: 1.1-2.6, = 0.03. Overall, 65.1% were aware of kidney NSAID-related side-effects and 22.4% were aware of the increased risk of asthma and allergy. Despite the high frequency of NSAID use in the Jordanian general population, there is limited knowledge of their side-effects as well as drug interactions. This is cause for concern, particularly as many participants reported having been prescribed NSAIDs by physicians without adequate patient safety education.
非甾体抗炎药（NSAIDs）常用于减轻疼痛、炎症和发热。本研究旨在评估约旦成年人中 NSAID 的使用模式和对 NSAID 相关副作用的认识，并探讨其与社会人口因素的关联。这项横断面研究在一个有代表性的 604 名年龄大于 18 岁的成年人样本中进行。使用经过验证的自我管理问卷从参与者那里收集基本的社会人口统计学数据，以及 NSAID 使用信息。大多数受访者是 NSAID 使用者（65.7%）、女性（53.4%）和 50 岁以下（74.5%）。总体而言，42.6%的人曾被医生开处 NSAIDs。男性性别和吸烟与 NSAIDs 使用呈负相关（多变量比值比[OR]：0.5，95%置信区间[CI]：0.4-0.8， = 0.001 和 OR：0.6，95% CI 0.4-0.8， = 0.003）。相比之下，卫生部医疗保险与 NSAIDs 使用相关，OR：1.6，95% CI：1.1-2.6， = 0.03。总体而言，65.1%的人意识到 NSAID 相关的肾脏副作用，22.4%的人意识到哮喘和过敏风险增加。尽管 NSAIDs 在约旦普通人群中的使用频率很高，但人们对其副作用以及药物相互作用的了解有限。这令人担忧，特别是许多参与者报告说他们曾被医生开处 NSAIDs，但没有接受充分的患者安全教育。
