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膀胱孤立性纤维瘤——一种罕见的潜在恶性肿瘤。

Solitary fibrous tumour of the urinary bladder - A rare and potentially malignant neoplasm.

作者信息

Ong Katherine, Singh Shivani, Swarbrick Nicole, Hayne Dickon

机构信息

Department of Urology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

Department of Anatomical Pathology, PathWest Laboratory Medicine WA, Western Australia, Australia.

出版信息

Urol Case Rep. 2023 Jul 17;50:102501. doi: 10.1016/j.eucr.2023.102501. eCollection 2023 Sep.

Abstract

Solitary fibrous tumours (SFTs) of the urinary bladder are a rare mesenchymal neoplasm that occasionally has malignant potential. The tumour is characterised by haphazardly arranged spindle-shaped to ovoid cells, with a prominent, branching, thin-walled, dilated vasculature and NAB2-STAT6 gene rearrangement. While most SFTs are indolent in nature, difficulty arises predicting which SFTs are potentially malignant. There are now validated risk stratification tools to help identify which SFTs are likely to metastasize and help clinicians determine management. The mainstay of treatment for SFTs remains surgery, with emerging evidence in the combined use of surgery and radiotherapy.

摘要

膀胱孤立性纤维瘤(SFTs)是一种罕见的间叶性肿瘤,偶尔具有恶性潜能。该肿瘤的特征是细胞呈梭形至卵圆形,排列杂乱,具有显著的、分支状的、薄壁的、扩张的脉管系统以及NAB2-STAT6基因重排。虽然大多数SFTs本质上是惰性的,但预测哪些SFTs具有潜在恶性却存在困难。目前已有经过验证的风险分层工具,以帮助识别哪些SFTs可能发生转移,并帮助临床医生确定治疗方案。SFTs的主要治疗方法仍然是手术,同时有新证据表明手术与放疗联合使用有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22b1/10387560/b34360a4e363/fx1.jpg

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