[新型严重急性呼吸综合征冠状病毒2感染后儿童多系统炎症综合征：4例临床分析]
[Multisystemic inflammatory syndrome in children after severe acute respiratory syndrome coronavirus 2 infection: a clinical analysis of four cases].
作者信息
Wang Fei, Liu Lu, Xue Ying, Dan Shi, An Xin-Jiang
机构信息
Department of Cardiology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221006, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Jul 15;25(7):685-688. doi: 10.7499/j.issn.1008-8830.2302126.
OBJECTIVES
To investigate the clinical features and treatment strategies of multisystemic inflammatory syndrome in children (MIS-C) after severe acute respiratory syndrome coronavirus 2 infection.
METHODS
A retrospective analysis was performed on the medical data of four children with MIS-C who were admitted to the Department of Cardiology, Xuzhou Children's Hospital, Xuzhou Medical Universityfrom January to February 2023.
RESULTS
All four children had multiple organ involvements and elevated inflammatory markers, with a poor response to standard therapy for Kawasaki disease after admission. Two children were treated with intravenous immunoglobulin therapy pulse therapy twice, and all four children were treated with glucocorticoids. The children had a good prognosis after the treatment.
CONCLUSIONS
MIS-C often appears within 4-6 weeks or a longer time after severe acute respiratory syndrome coronavirus 2 infection, and anti-inflammatory therapy in addition to the standard treatment regimen for Kawasaki disease can help to achieve a favorable treatment outcome.
目的
探讨儿童多系统炎症综合征（MIS-C）在严重急性呼吸综合征冠状病毒2感染后的临床特征及治疗策略。
方法
对2023年1月至2月在徐州医科大学附属徐州儿童医院心内科住院的4例MIS-C患儿的医疗资料进行回顾性分析。
结果
4例患儿均有多器官受累及炎症指标升高，入院后对川崎病标准治疗反应不佳。2例患儿接受了2次静脉注射免疫球蛋白脉冲治疗，4例患儿均接受了糖皮质激素治疗。治疗后患儿预后良好。
结论
MIS-C通常在严重急性呼吸综合征冠状病毒2感染后4-6周或更长时间出现，除川崎病标准治疗方案外，抗炎治疗有助于取得良好的治疗效果。
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