Kito T
Gan To Kagaku Ryoho. 1986 Sep;13(9):2699-707.
In this paper, we discuss the biological behavior considered important in surgical treatment for gastric cancer. Of the types of early gastric cancer, the Borrmann type, the histologically well differentiated type and that with metastasis to the lymph nodes belong to the high-risk group. In pm gastric cancer where cancer has infiltrated to the muscularis gropia, nearly 50% metastasis to the lymph node is observed. This is a therapeutic group for which removal of the lymph nodes is most effective. Of pm gastric cancer, the prognosis of the well differentiated type is poor. Adjuvant chemotherapy proves considerably effective for this type. When the relationship between the histologic type and prognosis is examined, the prognosis of the well differentiated type in pm is poor. As the cancer infiltrates to ss, and se, the prognosis of the poorly differentiated type, particularly the scirrhous type, becomes poor. Of the Borrmann IV type with the poorest prognosis among the various types of gastric cancer, there are two kinds, namely, that with a relatively good prognosis and the other with a very poor prognosis. The two can be classified macroscopically. These two groups appear to be different from each other in their biological behavior. Gastric cancer in the aged has a high percentage of metastasis to the lymph nodes, being characterized by a high incidence of Borrmann II type and multiple cancer. The prognosis is not necessarily poor.
在本文中，我们讨论了在胃癌外科治疗中被认为重要的生物学行为。在早期胃癌类型中，Borrmann型、组织学高分化型以及伴有淋巴结转移的类型属于高危组。在癌已浸润至胃壁肌层的进展期胃癌中，观察到近50%有淋巴结转移。这是一组淋巴结清扫最为有效的治疗对象。在进展期胃癌中，高分化型的预后较差。辅助化疗对该型相当有效。当检查组织学类型与预后的关系时，进展期高分化型的预后较差。随着癌浸润至浆膜下和浆膜层，低分化型，尤其是硬癌型的预后变差。在各类胃癌中预后最差的Borrmann Ⅳ型有两种，即预后相对较好的一种和预后非常差的一种。这两种可以在大体上进行分类。这两组在生物学行为上似乎彼此不同。老年胃癌的淋巴结转移率较高，其特征为Borrmann Ⅱ型和多发癌的发生率较高。其预后不一定差。
