Departments of Medical Oncology and Molecular Biology and Genetics, Mugla Sitki Kocman University, Mugla, Turkey.
Department of Internal Medicine, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
Indian J Cancer. 2023 Apr-Jun;60(2):282-291. doi: 10.4103/ijc.IJC_387_20.
Music and medicine can be used in patients with cancer as a palliative complementary therapy. It is aimed to show the effect of music therapy performed on anxiety, depression, and chemotherapy-related nausea/vomiting.
A total of 62 patients with colon cancer who previously experienced grade 1 or 2 chemotherapy-related nausea and vomiting were divided into two groups as intervention and control group based on the addition of music and medicine to infusion chemotherapies and 1:1 randomized. The groups were compared in terms of the effect of music and medicine on anxiety, depression, heart rate, blood pressure, and chemotherapy-related nausea-vomiting. Statistical analysis was done using SPSS Statistics for Windows, Version 19.0. A value of P < 0.05 was found statistically significant.
The patients were evaluated in terms of study variables at the beginning and after the completion of a chemotherapy session. As a result, there was a significant decrease in systolic blood pressure (P = 0.042), diastolic blood pressure (P = 0.44), heart rate (P = 0.046), state and trait sections of the state-trait anxiety inventory scores (P = 0.047 and P = 0.046, respectively), as well as a significant decrease in anxiety degree (P = 0.036) and a significant improvement in chemotherapy-related nausea (P = 0.021) and vomiting (P = 0.038) experience in the intervention group. However, no significant effect of music and medicine on depression was detected (P = 0.218).
Although it has not been shown to have an effect on depression, it was concluded that music and medicine with classical music integrated into the chemotherapy session can reduce the degree of nausea/vomiting and anxiety levels.
音乐和医学可以作为癌症患者的姑息性补充治疗方法。本研究旨在展示音乐疗法对焦虑、抑郁和化疗相关恶心/呕吐的疗效。
根据在输注化疗中加入音乐和药物的情况，将 62 例既往经历过 1 级或 2 级化疗相关恶心和呕吐的结肠癌患者分为干预组和对照组，每组 31 例。采用 1:1 随机分组。比较两组音乐和药物对焦虑、抑郁、心率、血压和化疗相关恶心-呕吐的影响。采用 SPSS Statistics for Windows，Version 19.0 进行统计学分析。P 值<0.05 为差异有统计学意义。
在化疗结束时评估患者的研究变量。结果显示，收缩压（P = 0.042）、舒张压（P = 0.44）、心率（P = 0.046）、状态-特质焦虑量表的状态和特质部分评分（P = 0.047 和 P = 0.046）均显著下降，焦虑程度显著降低（P = 0.036），且干预组化疗相关恶心（P = 0.021）和呕吐（P = 0.038）的程度显著改善。然而，音乐和药物对抑郁无显著影响（P = 0.218）。
尽管音乐和药物对抑郁没有影响，但本研究表明，将古典音乐融入化疗过程中的音乐和药物可以减轻恶心/呕吐和焦虑程度。
