Department of Stomatology, China-Japan Union Hospital of Jilin University, Changchun, China.
Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, China.
Biomed Pharmacother. 2023 Sep;165:115219. doi: 10.1016/j.biopha.2023.115219. Epub 2023 Aug 1.
Periodontitis and diabetes have a bidirectional link, making therapeutic treatment of periodontitis and diabetes challenging. Numerous factors, including microbes, inflammatory cytokines, immune cell activity, glucose levels, and metabolic disorders, contribute to the bidirectional relationship of periodontitis and diabetes. Basic periodontal treatment, medication, surgical treatment, and combined treatment are the most widely used treatments, but their efficacy are limited. Because of their capacity to support bone remodeling and tissue regeneration and restoration, reduce blood glucose levels, restore islet function, and ameliorate local and systemic inflammation, stem cell-derived exosomes have emerged as a possible therapeutic. In this review, we summarize the utilization of stem cell-derived exosomes in periodontitis and diabetes，discuss their potential mechanisms in periodontitis and diabetes bidirectional promoters. It provides some theoretical basis for using stem cell-derived exosomes to regulate the bidirectional link between periodontitis and diabetes.
牙周炎和糖尿病之间存在双向关联，使得牙周炎和糖尿病的治疗极具挑战性。许多因素，包括微生物、炎症细胞因子、免疫细胞活性、血糖水平和代谢紊乱，都促成了牙周炎和糖尿病之间的双向关系。基础牙周治疗、药物治疗、手术治疗和联合治疗是最常用的治疗方法，但疗效有限。由于干细胞衍生的外泌体具有支持骨重塑和组织再生与修复、降低血糖水平、恢复胰岛功能以及改善局部和全身炎症的能力，因此它们已成为一种有潜力的治疗方法。在这篇综述中，我们总结了干细胞衍生的外泌体在牙周炎和糖尿病中的应用，讨论了它们在牙周炎和糖尿病双向促进剂中的潜在机制。这为利用干细胞衍生的外泌体来调节牙周炎和糖尿病之间的双向联系提供了一些理论依据。
