Tanaka A, Sato M, Tsuchiya T, Adachi T, Niimura T, Yamaha T
Arch Toxicol. 1986 Jul;59(2):82-8. doi: 10.1007/BF00286728.
1,2,4-Trichlorobenzene (TCB) labeled with C-14 was given perorally to rats at a dosage of 50 mg/kg for excretion and distribution studies. About 66% and 17% of the oral dose was excreted in the urine and feces, respectively, within 7 days. Trapped radioactivity in the expired air amounted to 2.1% of the dose, but production of labeled carbon dioxide was negligible. Tissue residues were evenly distributed throughout the organs and tissues examined, except for the adipose tissue which consistently had a little higher concentration. The urinary, fecal and expiratory metabolites were identified. Free 2,4,5- and 2,3,5-trichlorophenol (TCP) and their conjugates were mainly detected in the urine. 5- or 6-Sulfhydryl, methylthio, methylsulfoxide and methylsulfone derivatives of TCB were also detected as minor metabolites. Dichlorobenzenes and unchanged TCB were confirmed in the expired air. Reductive dechlroination seems to be catalysed by intestinal microflora enzymes.
将标记有碳 - 14的1,2,4 - 三氯苯（TCB）以50毫克/千克的剂量经口给予大鼠，用于排泄和分布研究。在7天内，约66%的口服剂量经尿液排出，17%经粪便排出。呼出气体中的放射性截留量占剂量的2.1%，但标记二氧化碳的生成量可忽略不计。除脂肪组织中浓度始终略高外，组织残留量在所有检查的器官和组织中分布均匀。已鉴定出尿液、粪便和呼出气体中的代谢产物。尿液中主要检测到游离的2,4,5 - 和2,3,5 - 三氯苯酚（TCP）及其结合物。还检测到TCB的5 - 或6 - 巯基、甲硫基、甲亚砜和甲砜衍生物作为次要代谢产物。呼出气体中确认存在二氯苯和未变化的TCB。还原脱氯似乎由肠道微生物酶催化。
