Chu I, Villeneuve D C, Viau A, Barnes C R, Benoit F M, Qin Y H
J Toxicol Environ Health. 1984;13(4-6):777-86. doi: 10.1080/15287398409530539.
Adult male rats were given orally single doses of 14C-labeled 1,2,3,4-, 1,2,3,5-, or 1,2,4,5-tetrachlorobenzene (TCB) at 10 mg/kg body weight, and were housed in individual metabolism cages to collect urine and feces for radioassay. For 1,2,3,4- and 1,2,3,5-TCB, approximately 46-51% of the doses were excreted in urine and feces within 48 h after administration. During the same period only 8% of the administered 1,2,4,5-tetrachlorobenzene was excreted. Analysis of urine indicted that the tetrachlorobenzenes were biotransformed to a number of polar compounds. The metabolites for each of the three TCBs in decreasing order of quantities were as follows: 1,2,3,4-TCB, to 2,3,4,5- and 2,3,4,6-tetrachlorophenol and a trace of tetrachlorothiophenol and 2,3,4-trichlorophenol; 1,2,3,5-TCB, to 2,3,4,6-tetrachlorophenol, isomeric hydroxythrichlorothiophenols, and a trichlorophenol; 1,2,4,5-TCB, to 2,3,5,6-tetrachlorophenol, tetrachloroquinol, and a trichlorophenol.
给成年雄性大鼠经口单次给予10mg/kg体重的14C标记的1,2,3,4 -、1,2,3,5 -或1,2,4,5 -四氯苯（TCB），并将它们饲养在单独的代谢笼中以收集尿液和粪便用于放射性测定。对于1,2,3,4 -和1,2,3,5 - TCB，给药后48小时内约46 - 51%的剂量经尿液和粪便排出。在同一时期，所给予的1,2,4,5 -四氯苯仅有8%被排出。尿液分析表明四氯苯被生物转化为多种极性化合物。三种TCB各自的代谢产物按数量递减顺序如下：1,2,3,4 - TCB，转化为2,3,4,5 -和2,3,4,6 -四氯苯酚以及微量的四氯硫酚和2,3,4 -三氯苯酚；1,2,3,5 - TCB，转化为2,3,4,6 -四氯苯酚、异构羟基三氯硫酚和一种三氯苯酚；1,2,4,5 - TCB，转化为2,3,5,6 -四氯苯酚、四氯喹醇和一种三氯苯酚。
