Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
J Control Release. 2023 Sep;361:178-190. doi: 10.1016/j.jconrel.2023.07.056. Epub 2023 Aug 4.
Recently, there has been high interest in developing metal-organic framework (MOF) nanoparticles (NPs) for delivering therapeutic proteins, propelled mainly by the unique hierarchical porous structures of MOFs for protein encapsulation. Novel design strategies have emerged for broad therapeutic applications and clinical translations, leading to multifunctional MOF-NPs with improved biointerfacing capabilities and higher potency. This review summarizes recent MOF-NP designs specifically for protein delivery. The summary focuses on four design categories, including environment-responsive MOF-NPs for on-demand protein delivery, cell membrane-coated MOF-NPs for biomimetic protein delivery, cascade reaction-incorporated MOF-NPs for combinatorial protein delivery, and composite MOF-NPs for intelligent protein delivery. The major challenges and opportunities in using MOF-NPs for protein delivery are also discussed. Overall, this review will promote designs of MOF-NPs with unique properties to address unmet medical needs.
最近，人们对开发用于递送治疗性蛋白质的金属-有机骨架（MOF）纳米颗粒（NPs）产生了浓厚的兴趣，这主要得益于 MOF 独特的分级多孔结构，可用于蛋白质封装。为了实现广泛的治疗应用和临床转化，出现了新的设计策略，从而产生了具有改进的生物界面相互作用能力和更高效力的多功能 MOF-NPs。本综述总结了最近专门用于蛋白质递送的 MOF-NP 设计。综述重点介绍了四类设计，包括用于按需蛋白质递送的环境响应型 MOF-NPs、用于仿生蛋白质递送的细胞膜包覆型 MOF-NPs、用于组合蛋白质递送的级联反应整合型 MOF-NPs 以及用于智能蛋白质递送的复合 MOF-NPs。还讨论了使用 MOF-NPs 进行蛋白质递送的主要挑战和机遇。总的来说，本综述将促进具有独特性质的 MOF-NPs 的设计，以满足未满足的医疗需求。
