Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
J Vet Sci. 2023 Jul;24(4):e34. doi: 10.4142/jvs.22241.
There has not been a thoroughly reported study of the comparison between spectral domain-optical coherence tomography (SD-OCT) with both ultrasound biomicroscopy (UBM) and gonioscopy on the evaluation of the iridocorneal angle (ICA) in dogs.
To investigate the diagnostic value of SD-OCT for the early detection of narrowing ICA by comparing and assessing inter-device agreement in anterior chamber angle (ACA) measurements obtained by SD-OCT and UBM, and ICA evaluations by gonioscopy.
A total of 28 eyes from 28 client-owned dogs with normal intraocular pressure were included for examination. The ACA and angle opening distance (AOD) were measured from the SD-OCT and UBM images, and gonioscopy images were analyzed using the ICA grade and ZibWest angle index.
The mean ACA and AOD for SD-OCT were 28.31° ± 5.37° and 658.42 ± 219.90 µm, and for UBM, 28.34° ± 5.82° and 859.29 ± 221.80 µm, respectively. The mean difference in ACA between the average values of SD-OCT and UBM measurements was 0.03° with a 95% limit of agreement (LoA) span of 16.2°, indicating positive agreement; that in AOD was 200.85 µm with a 95% LoA span of 1,110.95 µm, indicating poor agreement. The Pearson correlation coefficient of the ACA of SD-OCT and ZibWest indices of gonioscopy was 0.624, indicating strong agreement; that of UBM and gonioscopy was 0.43, indicating moderate agreement.
SD-OCT is well tolerated by canine patients due to its non-contact method and might be an alternative option for early screening of ICA narrowing in clinical settings.
目前尚未有研究全面比较过光谱域光学相干断层扫描（SD-OCT）联合超声生物显微镜（UBM）和房角镜对犬眼前房角（ACA）的评估作用。
通过比较和评估 SD-OCT 和 UBM 测量的前房角（ACA）以及房角镜评估的虹膜角膜角（ICA），探讨 SD-OCT 对早期检测 ICA 变窄的诊断价值。
本研究纳入了 28 只眼压正常的犬的 28 只眼进行检查。从 SD-OCT 和 UBM 图像中测量 ACA 和房角开放距离（AOD），使用 ICA 分级和 ZibWest 角指数分析房角镜图像。
SD-OCT 的平均 ACA 和 AOD 分别为 28.31°±5.37°和 658.42±219.90 µm，UBM 分别为 28.34°±5.82°和 859.29±221.80 µm。SD-OCT 和 UBM 测量的平均值之间的 ACA 平均差异为 0.03°，95%一致性界限（LoA）跨度为 16.2°，表明存在正一致性；AOD 的平均差异为 200.85 µm，95%LoA 跨度为 1,110.95 µm，表明一致性差。SD-OCT 的 ACA 与房角镜的 ZibWest 指数的 Pearson 相关系数为 0.624，表明高度一致；UBM 与房角镜的相关性为 0.43，表明中度一致。
由于 SD-OCT 采用非接触式方法，犬患者易于接受，因此可能是临床早期筛查 ICA 变窄的一种替代方法。
