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多回波 Dixon 和 MRS 在定量肝脂肪含量和分期肝纤维化中的应用。

Application of multi-echo Dixon and MRS in quantifying hepatic fat content and staging liver fibrosis.

机构信息

Second Clinical School, Lanzhou University, Lanzhou, People's Republic of China.

Department of Magnetic Resonance, Lanzhou University Second Hospital, Cuiyingmen No.82, Chengguan District, Lanzhou, 730030, People's Republic of China.

出版信息

Sci Rep. 2023 Aug 2;13(1):12555. doi: 10.1038/s41598-023-39361-6.

DOI:10.1038/s41598-023-39361-6
PMID:37532757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10397311/
Abstract

This study associated the liver proton density fat fraction (PDFF), measured by multi-echo Dixon (ME-Dixon) and breath-hold single-voxel high-speed T2-corrected multi-echo H magnetic resonance spectroscopy (HISTO) at 1.5 T, with serum biomarkers and liver fibrosis stages. This prospective study enrolled 75 patients suspected of liver fibrosis and scheduled for liver biopsy and 23 healthy participants with normal liver function. The participant underwent ME-Dixon and HISTO scanning. The agreement of PDFF measured by ME-Dixon (PDFF-D) and HISTO (PDFF-H) were compared. Correlations between PDFF and serum fat biomarkers (total cholesterol, triglyceride, and high- and low-density lipoproteins) and the liver fibrosis stages were assessed. PDFF were compared among the liver fibrosis stages (F0-F4) based on clinical liver biopsies. The Bland-Altman plot showed agreement between PDFF-D and PDFF-H(LoA, - 4.44 to 6.75), which have high consistency (ICC 0.752, P < 0.001). The correlations with the blood serum markers were mild to moderate (PDFF-H: r = 0.261-0.410, P < 0.01; PDFF-D: r = 0.265-0.367, P < 0.01). PDFF-D, PDFF-H, and steatosis were distributed similarly among the liver fibrosis stages. PDFF-H showed a slight negative correlation with the liver fibrosis stages (r = - 0.220, P = 0.04). Both ME-Dixon and HISTO sequences measured liver fat content noninvasively. Liver fat content was not directly associated with liver fibrosis stages.

摘要

本研究将多回波 Dixon（ME-Dixon）测量的肝脏质子密度脂肪分数（PDFF）与 1.5T 呼吸门控单容积高速 T2 校正多回波 H 磁共振波谱（HISTO）的血清生物标志物和肝纤维化分期相关联。这项前瞻性研究纳入了 75 名疑似肝纤维化并计划进行肝活检的患者和 23 名肝功能正常的健康参与者。参与者接受了 ME-Dixon 和 HISTO 扫描。比较了 ME-Dixon（PDFF-D）和 HISTO（PDFF-H）测量的 PDFF 的一致性。评估了 PDFF 与血清脂肪生物标志物（总胆固醇、甘油三酯和高低密度脂蛋白）和肝纤维化分期之间的相关性。根据临床肝活检，比较了肝纤维化分期（F0-F4）之间的 PDFF。Bland-Altman 图显示 PDFF-D 和 PDFF-H（LoA，-4.44 至 6.75）之间具有一致性（ICC 0.752，P<0.001）。与血清标志物的相关性为轻度至中度（PDFF-H：r=0.261-0.410，P<0.01；PDFF-D：r=0.265-0.367，P<0.01）。PDFF-D、PDFF-H 和脂肪变性在肝纤维化分期中分布相似。PDFF-H 与肝纤维化分期呈轻微负相关（r=-0.220，P=0.04）。ME-Dixon 和 HISTO 序列均可无创测量肝脏脂肪含量。肝脏脂肪含量与肝纤维化分期没有直接关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/8587d6267b2d/41598_2023_39361_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/02ffad9e920b/41598_2023_39361_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/dd5012b43a46/41598_2023_39361_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/9c0e67f941c4/41598_2023_39361_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/d4f3a4d79b1f/41598_2023_39361_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/8587d6267b2d/41598_2023_39361_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/02ffad9e920b/41598_2023_39361_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/dd5012b43a46/41598_2023_39361_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/9c0e67f941c4/41598_2023_39361_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/d4f3a4d79b1f/41598_2023_39361_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c2/10397311/8587d6267b2d/41598_2023_39361_Fig5_HTML.jpg

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