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日本临床实践中高血压管理的横断面调查:与日本医学会临床医学数据库合作进行的 2021 年神奈川高血压研究。

Cross-sectional survey of hypertension management in clinical practice in Japan: the Kanagawa Hypertension Study 2021 conducted in collaboration with Japan Medical Association Database of Clinical Medicine.

机构信息

Committee of Hypertension and Kidney Disease, Kanagawa Physicians Association, Yokohama, Japan.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.

出版信息

Hypertens Res. 2023 Nov;46(11):2447-2459. doi: 10.1038/s41440-023-01366-z. Epub 2023 Aug 2.

DOI:10.1038/s41440-023-01366-z
PMID:37532949
Abstract

We aim to assess the data of patients with hypertension in Kanagawa Prefecture, Japan, collected in 2021 that were provided by the Japan Medical Association Database of Clinical Medicine. Data collected in 2011 and 2014 by the Kanagawa Physicians Association were used for comparative analysis. The target blood pressure (BP) achievement rates for patients whose target office and home BP were <140/90 mmHg and <135/85 mmHg, respectively, were 72.5% and 75.8% in 2011, 66.0% and 68.5% in 2014, and 46.7% and 83.3% in 2021, respectively. The target office BP achievement rate in 2021 was significantly lower than those in 2011 and 2014 (p ≤ 0.009). In contrast, there was no significant difference and improvement of the achievement rates for patients whose target office and home BP were <130/80 mmHg and <125/75 mmHg, respectively, among the three surveys. After the Japanese Society of Hypertension 2019 Guidelines were released, the achievement rates for patients whose target BP was tightened were significantly lower than those for patients with unchanged target BP (office/home, p < 0.001/0.04). The proportion of the patients who achieved their office and home target BP using more than three drugs was 38.5% and 20.0%, respectively. In the present analysis, we unveiled the current problems encountered in the clinical management of hypertension in Japan. In particular, efforts should be focused on the management of patients that require strict BP control.

摘要

我们旨在评估日本神奈川县 2021 年收集的、由日本医师协会临床医学数据库提供的高血压患者数据,并与神奈川县医师协会在 2011 年和 2014 年收集的数据进行比较分析。目标诊室和家庭血压分别<140/90mmHg 和<135/85mmHg 的患者的目标血压达标率在 2011 年分别为 72.5%和 75.8%,在 2014 年分别为 66.0%和 68.5%,在 2021 年分别为 46.7%和 83.3%。2021 年的目标诊室血压达标率显著低于 2011 年和 2014 年(p≤0.009)。相比之下,在这三项调查中,目标诊室和家庭血压分别<130/80mmHg 和<125/75mmHg 的患者的达标率没有显著差异和改善。日本高血压学会 2019 指南发布后,目标血压收紧患者的达标率显著低于目标血压不变患者(诊室/家庭,p<0.001/0.04)。使用超过三种药物来达到诊室和家庭目标血压的患者比例分别为 38.5%和 20.0%。在本分析中,我们揭示了日本高血压临床管理中当前面临的问题。特别是,应重点关注需要严格血压控制的患者的管理。

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沙库巴曲缬沙坦与氨氯地平治疗日本原发性高血压患者的疗效和安全性:一项随机、多中心、开放标签、非劣效性研究(PARASOL研究)。
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