Edwards J R, Wroth R, de Chaneet G C, Besier R B, Karlsson J, Morcombe P W, Dalton-Morgan G, Roberts D
Aust Vet J. 1986 May;63(5):139-44. doi: 10.1111/j.1751-0813.1986.tb02951.x.
Owners of 116 farms, whose flocks had been tested for anthelmintic resistance, were interviewed to determine their use of various sheep management and parasite control practices and their knowledge and adoption of recommended procedures for the prevention and control of resistance. Farmers knowledge of current recommendations related mainly to changing drenches and drench groups. Other aspects of the recommended program including reduction of drenching frequency and the use of alternative management strategies were not considered as important by farmers. For most questions a high proportion of farmers (greater than 20%) had no opinion. Associations between various strategies for nematode control and resistance of Trichostrongylus and Teladorsagia to thiabendazole and levamisole were examined. These relationships differed between anthelmintics and nematode genera. A number of factors were related to resistance of one or both nematode genera to one or both anthelmintic groups. These factors included flock size, percentage of ewes in the flock, cattle number, main sheep production activity, grazing strategy, frequency of drenching, changes in the frequency of drenching, number of summer drenches and the method of estimating dose rates. It was concluded that the methods employed to control anthelmintic resistance may vary with the nematode, its resistance status and the anthelmintic to which it is exposed. Modifications to the previously recommended program have been proposed which incorporate selection of the anthelmintic to be used following a test for anthelmintic resistance.
对116个农场的场主进行了访谈，这些农场的羊群已接受抗驱虫药耐药性检测，目的是确定他们对各种绵羊管理和寄生虫控制措施的使用情况，以及他们对预防和控制耐药性的推荐程序的了解和采用情况。农民对当前建议的了解主要涉及更换驱虫药和驱虫药组合。农民并不认为推荐方案的其他方面（包括降低驱虫频率和使用替代管理策略）很重要。对于大多数问题，很大比例的农民（超过20%）没有看法。研究了各种线虫控制策略与毛圆线虫属和奥斯特线虫属对噻苯达唑和左旋咪唑耐药性之间的关联。这些关系在驱虫药和线虫属之间有所不同。一些因素与一种或两种线虫属对一种或两种驱虫药组的耐药性有关。这些因素包括羊群规模、羊群中母羊的比例、牛的数量、主要的绵羊生产活动、放牧策略、驱虫频率、驱虫频率的变化、夏季驱虫次数以及剂量率的估算方法。得出的结论是，控制抗驱虫药耐药性所采用的方法可能因线虫、其耐药状态以及所接触的驱虫药而异。已提出对先前推荐方案的修改建议，其中包括在进行抗驱虫药耐药性检测后选择要使用的驱虫药。
