Sakai Yoshihito, Watanabe Tsuyoshi, Wakao Norimitsu, Matsui Hiroki, Osada Naoaki, Kaneko Reina, Watanabe Ken
National Center for Geriatrics and Gerontology, Obu City, Aichi Prefecture, Japan.
Gerontol Geriatr Med. 2023 Jul 31;9:23337214231190146. doi: 10.1177/23337214231190146. eCollection 2023 Jan-Dec.
The prevalence of chronic pain increases with age. It has been reported that chronic pain is associated with sarcopenia and obesity. Age-related skeletal muscle loss and fat gain are known to occur due to chronic inflammation. The aim of this study was to analyze how skeletal muscle and fat, caused by chronic inflammation due to aging, regulate the development of geriatric chronic pain. The results of skeletal muscle and fat mass, 412 participants aged ≥65 years with non-specific chronic pain lasting ≥6 months, including low back, neck, and knee pain, was compared with the control without chronic pain. Body composition threshold regulating chronic pain was calculated. A significantly lower skeletal muscle mass index and higher body fat percentage were observed in patients with chronic pain than that in the control. The muscle fat ratio (MFR) was significantly lower in the chronic pain group than in the control group. When the MFR threshold related to chronic pain was calculated by sex, it was 2.984 for men and 1.867 for women. Evaluation of the body composition of elderly patients with non-specific chronic pain revealed that the MFR was useful as an index related to chronic pain.
慢性疼痛的患病率随年龄增长而增加。据报道，慢性疼痛与肌肉减少症和肥胖有关。已知由于慢性炎症会导致与年龄相关的骨骼肌流失和脂肪增加。本研究的目的是分析因衰老引起的慢性炎症导致的骨骼肌和脂肪如何调节老年慢性疼痛的发展。对412名年龄≥65岁、患有持续≥6个月的非特异性慢性疼痛（包括腰、颈和膝痛）的参与者的骨骼肌和脂肪量结果与无慢性疼痛的对照组进行了比较。计算了调节慢性疼痛的身体成分阈值。与对照组相比，慢性疼痛患者的骨骼肌质量指数显著降低，体脂百分比更高。慢性疼痛组的肌肉脂肪比（MFR）显著低于对照组。按性别计算与慢性疼痛相关的MFR阈值时，男性为2.984，女性为1.867。对患有非特异性慢性疼痛的老年患者的身体成分评估表明，MFR作为与慢性疼痛相关的指标是有用的。
