洗牙与自发性颅内出血风险降低

Dental scaling and lower risk of spontaneous intracranial hemorrhage.

作者信息

Kao Yi-Wei, Ye Linglong, Qin Lei, Cheng Hsin-Chung, Deng Win-Ping, Pan Jin-Shui, Shia Ben-Chang, Kang De-Zhi

机构信息

Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei, Taiwan.

Research Center of Big Data, College of Management, Taipei Medical University, Taipei, Taiwan.

出版信息

Heliyon. 2023 Jul 19;9(8):e18431. doi: 10.1016/j.heliyon.2023.e18431. eCollection 2023 Aug.

DOI:10.1016/j.heliyon.2023.e18431

PMID:37534008

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10391939/

Abstract

BACKGROUND

Spontaneous intracranial hemorrhage (ICH) has high fatality while has few proven treatments. We aim at investigating the association between dental scaling (DS) and the risk of ICH.

METHODS

In this cohort study, two cohorts were matched by propensity score based on potential confounders. Data from ICH between January 2008 and December 2014 in Taiwan were analyzed. The subjects underwent DS at least 6 times between January 1, 2002, and December 31, 2007, while the matched controls did not undergo any DS during the same period. Cumulative incidences and hazard ratios (HRs) were calculated after adjusting for competing confounders.

RESULTS

Each cohort consisted of 681,126 subjects. Compared with the non-DS cohort, the regular-DS cohort had a significantly lower incidence of ICH (0.8% vs 1.2%; P < 0.0001), and the adjusted hazards ratio (aHR) of 7-year ICH was 0.61 (95% confidence interval, CI, 0.59-0.63; P < 0.0001). The 30-39-year age group of the regular-DS cohort had the lowest HR (0.57; 95% CI, 0.52-0.61; P < 0.0001) of 7-year ICH when compared with similar controls. Compared with the controls, the regular-DS cohort also had significantly lower HR (0.82; 95% CI, 0.81-0.82; P < 0.0001) of 7-year hypertension. Compared with those without DS, the lowest risk of intracerebral hemorrhage was observed in the male participants with regular DS (0.43; 95% CI, 0.40-0.47; P < 0.0001).

CONCLUSIONS

Regular DS was consistently associated with lower ICH risk in subjects aged 30-59 years, which may benefit from the decreased HBP risk. DS had a potential role in the prophylaxis for ICH, a condition with a high disability or mortality.

摘要

背景

自发性颅内出血（ICH）致死率高，而经证实的治疗方法却很少。我们旨在研究洗牙（DS）与ICH风险之间的关联。

方法

在这项队列研究中，根据潜在混杂因素通过倾向评分对两个队列进行匹配。分析了2008年1月至2014年12月台湾地区ICH的数据。研究对象在2002年1月1日至2007年12月31日期间至少接受了6次洗牙，而匹配的对照组在同一时期未接受任何洗牙。在对竞争性混杂因素进行调整后计算累积发病率和风险比（HRs）。

结果

每个队列由681,126名受试者组成。与未洗牙队列相比，定期洗牙队列的ICH发病率显著较低（0.8%对1.2%；P < 0.0001），7年ICH的调整后风险比（aHR）为0.61（95%置信区间，CI，0.59 - 0.63；P < 0.0001）。与相似对照组相比，定期洗牙队列中30 - 39岁年龄组的7年ICH风险比最低（0.57；95% CI，0.52 - 0.61；P < 0.0001）。与对照组相比，定期洗牙队列的7年高血压风险比也显著较低（0.82；95% CI，0.81 - 0.82；P < 0.0001）。与未洗牙者相比，定期洗牙的男性参与者脑出血风险最低（0.43；95% CI，0.40 - 0.47；P < 0.0001）。