Mangone Lucia, Penna Domenico, Marinelli Francesco, Roncaglia Francesca, Bisceglia Isabella, Merli Francesco, Ruffini Alessia, Gamberi Barbara, Tieghi Alessia, Valli Riccardo, Albertazzi Laura, Iori Mauro, Giorgi Rossi Paolo, Vener Claudia, Morabito Fortunato, Neri Antonino, Luminari Stefano
Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
PhD Program in Clinical and Experimental Medicine, University of Modena and, Reggio Emilia, Italy.
Front Oncol. 2023 Jul 18;13:1182971. doi: 10.3389/fonc.2023.1182971. eCollection 2023.
Hematological malignancies (HMs) represent a heterogeneous group of diseases with diverse etiology, pathogenesis, and prognosis. HMs' accurate registration by Cancer Registries (CRs) is hampered by the progressive de-hospitalization of patients and the transition to molecular rather than microscopic diagnosis.
A dedicated software capable of automatically identifying suspected HMs cases by combining several databases was adopted by Reggio Emilia Province CR (RE-CR). Besides pathological reports, hospital discharge archives, and mortality records, RE-CR retrieved information from general and biomolecular laboratories. Incidence, mortality, and 5-year relative survival (RS) reported according to age, sex, and 4 HMs' main categories, were noted.
Overall, 7,578 HM cases were diagnosed from 1996 to 2020 by RE-CR. HMs were more common in males and older patients, except for Hodgkin Lymphoma and Follicular Lymphoma (FL). Incidence showed a significant increase for FL (annual percent change (APC)=3.0), Myeloproliferative Neoplasms (MPN) in the first period (APC=6.0) followed by a significant decrease (APC=-7.4), and Myelodysplastic Syndromes (APC=16.4) only in the first period. Over the years, a significant increase was observed in 5-year RS for Hodgkin -, Marginal Zone -, Follicular - and Diffuse Large B-cell-Lymphomas, MPN, and Acute Myeloid Leukemia. The availability of dedicated software made it possible to recover 80% of cases automatically: the remaining 20% required direct consultation of medical records.
The study emphasizes that HM registration needs to collect information from multiple sources. The digitalization of CRs is necessary to increase their efficiency.
血液系统恶性肿瘤（HMs）是一组病因、发病机制和预后各异的异质性疾病。患者的逐步非住院化以及诊断向分子而非显微镜诊断的转变阻碍了癌症登记处（CRs）对HMs的准确登记。
雷焦艾米利亚省癌症登记处（RE-CR）采用了一款能够通过整合多个数据库自动识别疑似HMs病例的专用软件。除了病理报告、医院出院档案和死亡记录外，RE-CR还从普通和生物分子实验室检索信息。记录了根据年龄、性别和4种主要HMs类别报告的发病率、死亡率和5年相对生存率（RS）。
总体而言，1996年至2020年期间，RE-CR共诊断出7578例HM病例。除霍奇金淋巴瘤和滤泡性淋巴瘤（FL）外，HMs在男性和老年患者中更为常见。FL的发病率显著增加（年度百分比变化（APC）=3.0），骨髓增殖性肿瘤（MPN）在第一阶段显著增加（APC=6.0），随后显著下降（APC=-7.4），而骨髓增生异常综合征仅在第一阶段发病率显著增加（APC=16.4）。多年来，霍奇金淋巴瘤、边缘区淋巴瘤、滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤、MPN以及急性髓系白血病的5年RS显著增加。专用软件的使用使得80%的病例能够自动找回：其余20%需要直接查阅病历。
该研究强调，HM登记需要从多个来源收集信息。CRs的数字化对于提高其效率是必要的。
