Department of Psychology, Dalian Medical University, 9 South LvShun Road, Dalian, 116044, China.
Departments of Ophthalmology, Developmental Biology, and Microbiology & Molecular Genetics, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Biol Rev Camb Philos Soc. 2023 Dec;98(6):2271-2283. doi: 10.1111/brv.13006. Epub 2023 Aug 3.
Neurulation transforms the neuroectoderm into the neural tube. This transformation relies on reorganising the configurational relationships between the orientations of intrinsic polarities of neighbouring cells. These orientational intercellular relationships are established, maintained, and modulated by orientational cell adhesions (OCAs). Here, using zebrafish (Danio rerio) neurulation as a major model, we propose a new perspective on how OCAs contribute to the parallel, antiparallel, and opposing intercellular relationships that underlie the neural plate-keel-rod-tube transformation, a stepwise process of cell aggregation followed by cord hollowing. We also discuss how OCAs in neurulation may be regulated by various adhesion molecules, including cadherins, Eph/Ephrins, Claudins, Occludins, Crumbs, Na /K -ATPase, and integrins. By comparing neurulation among species, we reveal that antiparallel OCAs represent a conserved mechanism for the fusion of the neural tube. Throughout, we highlight some outstanding questions regarding OCAs in neurulation. Answers to these questions will help us understand better the mechanisms of tubulogenesis of many tissues.
神经胚形成将神经外胚层转化为神经管。这种转化依赖于重新组织相邻细胞固有极性方向之间的构形关系。这些定向的细胞间关系通过定向细胞粘附（OCA）建立、维持和调节。在这里，我们使用斑马鱼（Danio rerio）神经胚形成作为主要模型，提出了一个新的观点，即 OCA 如何有助于平行、反平行和相反的细胞间关系，这些关系是神经板-龙骨-棒-管转化的基础，这是一个细胞聚集随后管腔化的逐步过程。我们还讨论了神经胚形成中的 OCA 如何受到各种粘附分子的调节，包括钙粘蛋白、Eph/Ephrins、Claudins、Occludins、Crumbs、Na+/K+-ATP 酶和整合素。通过比较不同物种的神经胚形成，我们揭示了反平行 OCA 代表了神经管融合的保守机制。贯穿全文，我们强调了神经胚形成中 OCA 的一些悬而未决的问题。对这些问题的回答将帮助我们更好地理解许多组织的管状发生机制。
