Behm R, Habeck J O, Huckstorf C, Honig A
Biomed Biochim Acta. 1986;45(6):787-93.
Spontaneously hypertensive rats (SHR) of the Okamoto-Aoki strain grew up in low pressure chambers at a simulated altitude of 4000 m from their 5th to their 18th week of age. Both the sea-level control rats and the hypoxic rats were divided into groups with and without additional hypertonic salt solution. Due to chronic hypoxia the development of systemic hypertension and the left ventricular hypertrophy were diminished in young SHR. In contrast to adult SHR, these effects were attenuated but not abolished by addition of salt. Independently of the salt availability, exposure to long-lasting hypoxia increases the carotid body volume significantly. The data indicate that chronic hypoxia has a stronger effect on carotid body enlargement than different levels of the systemic arterial blood pressure.
冈本-青木品系的自发性高血压大鼠（SHR）在海拔4000米模拟高度的低压舱中从5周龄生长至18周龄。海平面对照大鼠和低氧大鼠均被分为添加和不添加高渗盐溶液的组。由于慢性低氧，年轻SHR的系统性高血压和左心室肥大的发展有所减弱。与成年SHR不同，添加盐可减弱但并未消除这些影响。无论盐的供应情况如何，长期暴露于低氧环境会显著增加颈动脉体体积。数据表明，慢性低氧对颈动脉体增大的影响比对不同水平的系统性动脉血压的影响更强。
