Behm R, Honig A, Griethe M, Schmidt M, Schneider P
Biomed Biochim Acta. 1984;43(7):975-85.
Spontaneously hypertensive rats (SHR) of the Okamoto-Aoki-strain (n = 20) and normotensive rats (NCR) of a random-bred Wistar strain (n = 20) were kept in low-pressure chambers for 13 days at sea-level atmospheric pressure, then for 20 days at a simulated altitude of 4000 m, and subsequently again for 10 days at sea-level. The unrestrained animals were placed singly in metabolic cages and had free access to food, water, and a 2.5% NaC1-solution. Exposure to hypobaric hypoxia led to a transient decrease of daily food and water intake in both strains of animals and a slight reduction of saline consumption in the NCR. In contrast, the SHR showed a massive and sustained suppression of their voluntary intake of hypertonic saline throughout high-altitude exposure. Renal electrolyte and water excretion followed the reactions of salt and water intake. - In an additional series of experiments it was found that SH-rats react with a decrease of their systemic arterial blood pressures in hypobaric hypoxia only on condition that food and water but no additional salt is available to the animals. The data suggest that the antihypertensive effects of chronic high-altitude hypoxia depend both on the availability of salt and a reduction of salt appetite.
将冈本-青木品系的自发性高血压大鼠（SHR，n = 20）和随机繁殖的Wistar品系的正常血压大鼠（NCR，n = 20）在海平面大气压下置于低压舱中13天，然后在模拟海拔4000米的高度下放置20天，随后再次在海平面放置10天。将未受限制的动物单独置于代谢笼中，使其能够自由获取食物、水和2.5%的NaCl溶液。暴露于低压低氧环境导致两种品系动物的每日食物和水摄入量短暂减少，NCR的盐水消耗量略有降低。相比之下，在整个高海拔暴露过程中，SHR的高渗盐水自愿摄入量出现大量且持续的抑制。肾脏电解质和水排泄情况与盐和水摄入量的反应一致。 - 在另一系列实验中发现，只有当动物能够获取食物和水但没有额外盐分供应时，SH大鼠在低压低氧环境中才会出现全身动脉血压下降。数据表明，慢性高海拔低氧的降压作用既取决于盐分的可获得性，也取决于盐食欲的降低。
