The Third Clinical Medical College, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, People's Republic of China.
The Third Affiliated Hospital of Zhejiang Chinese Medical University, 310013 Hangzhou, Zhejiang, People's Republic of China.
J Spinal Cord Med. 2024 Nov;47(6):840-849. doi: 10.1080/10790268.2023.2214482. Epub 2023 Aug 3.
To discuss the efficacy of exoskeleton robotic training on ambulation recovery in patients with spinal cord injury (SCI). PubMed, Embase, and Cochrane Central Register of Controlled Trials were searched systematically from their inception to April 2022 for studies on exoskeleton robotic training in patients with SCI. The language was restricted to English. The retrieved studies were screened to select eligible clinical trials. Meta-analysis was performed using Review Manager 5.4. Eleven randomized clinical trials (RCTs) involving 456 participants were included in the meta-analysis. The results of the meta-analysis showed that exoskeleton robotic training was more effective in improving FIM [SMD = 0.58, 95%CI = (0.07, 1.10), = 0.03], LEMS [MD = 4.64, 95%CI = (3.58, 5.70), <0.05], MAS [MD = 0.76, 95%CI = (0.48, 1.03), <0.05] and BBS [MD = -3.11, 95%CI = (-12.59, 6.36), <0.05] in patients with SCI, compared to conventional gait training(CGT). Subgroup analysis showed that the exoskeleton robotic could significantly improve the walking endurance and walking speed of patients with a duration of injury within 6 months. The sensitivity of inverted funnel plot analysis is low, suggesting that the analysis results of this study are relatively stable. Exoskeleton robotic training improves ambulation in patients with SCI, especially for patients with a course of injury within six months.
探讨外骨骼机器人训练对脊髓损伤（SCI）患者步行恢复的疗效。系统检索 PubMed、Embase 和 Cochrane 中央对照试验注册库，从建库至 2022 年 4 月，检索外骨骼机器人训练治疗 SCI 患者的相关研究。语言限制为英语。筛选检索到的研究以选择合格的临床试验。使用 Review Manager 5.4 进行 Meta 分析。纳入 11 项随机临床试验（RCT），共 456 名参与者进行 Meta 分析。Meta 分析结果表明，外骨骼机器人训练在改善 FIM [SMD=0.58，95%CI=（0.07，1.10），=0.03]、LEMS [MD=4.64，95%CI=（3.58，5.70），<0.05]、MAS [MD=0.76，95%CI=（0.48，1.03），<0.05]和 BBS [MD=-3.11，95%CI=（-12.59，6.36），<0.05]方面更有效SCI 患者，与常规步态训练（CGT）相比。亚组分析表明，外骨骼机器人可以显著提高损伤持续时间在 6 个月内的患者的步行耐力和步行速度。倒漏斗图分析的敏感性较低，表明本研究的分析结果相对稳定。外骨骼机器人训练可改善 SCI 患者的步行能力，特别是损伤病程在 6 个月内的患者。
