Laboratory of Phytopathology, Wageningen University and Research, Wageningen, the Netherlands.
Department of Plant Pathology, Kansas State University, Manhattan, Kansas, United States of America.
PLoS Pathog. 2023 Aug 3;19(8):e1011525. doi: 10.1371/journal.ppat.1011525. eCollection 2023 Aug.
Through the association of protein complexes to DNA, the eukaryotic nuclear genome is broadly organized into open euchromatin that is accessible for enzymes acting on DNA and condensed heterochromatin that is inaccessible. Chemical and physical alterations to chromatin may impact its organization and functionality and are therefore important regulators of nuclear processes. Studies in various fungal plant pathogens have uncovered an association between chromatin organization and expression of in planta-induced genes that are important for pathogenicity. This review discusses chromatin-based regulation mechanisms as determined in the fungal plant pathogen Verticillium dahliae and relates the importance of epigenetic transcriptional regulation and other nuclear processes more broadly in fungal plant pathogens.
通过蛋白质复合物与 DNA 的结合，真核核基因组被广泛组织成开放的常染色质，这些常染色质可被作用于 DNA 的酶访问，而浓缩的异染色质则不可访问。染色质的化学和物理改变可能会影响其组织和功能，因此是核过程的重要调节剂。在各种真菌植物病原体中的研究揭示了染色质组织与在植物中诱导的基因表达之间的关联，这些基因对于致病性很重要。本综述讨论了在真菌植物病原体黄萎病菌中确定的基于染色质的调节机制，并更广泛地涉及了真菌植物病原体中表观遗传转录调节和其他核过程的重要性。
