Korea Institute of Science and Technology, Bionics Research Center, Seoul, Korea Repub.
Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Korea Repub.
PLoS One. 2023 Aug 3;18(8):e0289266. doi: 10.1371/journal.pone.0289266. eCollection 2023.
Early detection of venous congestion (VC)-related diseases such as deep vein thrombosis (DVT) is important to prevent irreversible or serious pathological conditions. However, the current way of diagnosing DVT is only possible after recognizing advanced DVT symptoms such as swelling, pain, and tightness in affected extremities, which may be due to the lack of information on neuromechanical changes following VC. Thus, the goal of this study was to investigate acute neuromechanical changes in muscle electrical activity and muscle stiffness when VC was induced. The eight pigs were selected and the change of muscle stiffness from the acceleration and muscle activity in terms of integral electromyography (IEMG) was investigated in three VC stages. Consequently, we discovered a significant increase in the change in muscle stiffness and IEMG from the baseline to the VC stages (p < 0.05). Our results and approach can enable early detection of pathological conditions associated with VC, which can be a basis for further developing early diagnostic tools for detecting VC-related diseases.
早期发现静脉淤血（VC）相关疾病，如深静脉血栓（DVT），对于预防不可逆或严重的病理状况非常重要。然而，目前诊断 DVT 的方法只能在识别出肿胀、疼痛和受影响肢体紧绷等晚期 DVT 症状后才能进行，这可能是因为缺乏关于 VC 后神经机械变化的信息。因此，本研究的目的是研究 VC 诱导时肌肉电活动和肌肉僵硬的急性神经机械变化。选择了 8 头猪，并在三个 VC 阶段研究了肌肉僵硬的加速度和整体肌电图（IEMG）方面的肌肉活动变化。结果发现，从基线到 VC 阶段，肌肉僵硬和 IEMG 的变化显著增加（p < 0.05）。我们的结果和方法可以实现与 VC 相关的病理状况的早期检测，这可以为进一步开发用于检测 VC 相关疾病的早期诊断工具提供基础。
