肠道上皮细胞调节真菌发病机制。
Gut epithelium modulates fungal pathogenesis.
机构信息
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
出版信息
Science. 2023 Aug 4;381(6657):483-484. doi: 10.1126/science.adj1240. Epub 2023 Aug 3.
Abstract
Specialized epithelium secretes an antifungal peptide.
摘要
特化的上皮细胞分泌一种抗真菌肽。
相似文献
1
Gut epithelium modulates fungal pathogenesis.肠道上皮细胞调节真菌发病机制。
Science. 2023 Aug 4;381(6657):483-484. doi: 10.1126/science.adj1240. Epub 2023 Aug 3.
2
Peptide YY: A Paneth cell antimicrobial peptide that maintains gut commensalism.肽 YY：一种潘氏细胞抗菌肽，可维持肠道共生。
Science. 2023 Aug 4;381(6657):502-508. doi: 10.1126/science.abq3178. Epub 2023 Aug 3.
3
Regulation of Paneth Cell Function by RNA-Binding Proteins and Noncoding RNAs.RNA 结合蛋白和非编码 RNA 对潘氏细胞功能的调节。
Cells. 2021 Aug 17;10(8):2107. doi: 10.3390/cells10082107.
4
Peptide YY/neuropeptide Y Y1 receptor expression in the epithelium and mucosal nerves of the human colon.肽YY/神经肽Y Y1受体在人结肠上皮和黏膜神经中的表达
Regul Pept. 1999 Aug 31;83(1):11-9. doi: 10.1016/s0167-0115(99)00035-x.
5
Peptide YY as a growth factor for intestinal epithelium.肽YY作为肠上皮的生长因子。
Peptides. 2002 Feb;23(2):383-8. doi: 10.1016/s0196-9781(01)00615-5.
6
Gut Microbiota as a Modulator of Paneth Cells During Parenteral Nutrition in Mice.肠道微生物群作为小鼠肠外营养期间潘氏细胞的调节剂。
JPEN J Parenter Enteral Nutr. 2018 Nov;42(8):1280-1287. doi: 10.1002/jpen.1162. Epub 2018 Apr 27.
7
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.自噬及自噬基因Atg16l1在小鼠和人类肠道潘氏细胞中的关键作用。
Nature. 2008 Nov 13;456(7219):259-63. doi: 10.1038/nature07416. Epub 2008 Oct 5.
8
Lack of peptide YY signaling in mice disturbs gut microbiome composition in response to high-fat diet.缺乏肽 YY 信号会干扰高脂肪饮食下小鼠肠道微生物组的组成。
FASEB J. 2021 Apr;35(4):e21435. doi: 10.1096/fj.202002215R.
9
Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation.条件性双等位基因 Apc 失活诱导的小鼠结肠腺瘤状上皮中 Sox9 的诱导、异位 Paneth 细胞和有丝分裂纺锤体轴缺陷。
Am J Pathol. 2013 Aug;183(2):493-503. doi: 10.1016/j.ajpath.2013.04.013. Epub 2013 Jun 13.
10
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.SOX9是肠道上皮中潘氏细胞分化所必需的。
Gastroenterology. 2007 Aug;133(2):539-46. doi: 10.1053/j.gastro.2007.05.020. Epub 2007 May 21.
本文引用的文献
1
Peptide YY: A Paneth cell antimicrobial peptide that maintains gut commensalism.肽 YY：一种潘氏细胞抗菌肽，可维持肠道共生。
Science. 2023 Aug 4;381(6657):502-508. doi: 10.1126/science.abq3178. Epub 2023 Aug 3.
2
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity.粘蛋白 O-聚糖是白色念珠菌致病性的天然抑制剂。
Nat Chem Biol. 2022 Jul;18(7):762-773. doi: 10.1038/s41589-022-01035-1. Epub 2022 Jun 6.
3
Immune regulation by fungal strain diversity in inflammatory bowel disease.真菌菌株多样性对炎症性肠病的免疫调节。
Nature. 2022 Mar;603(7902):672-678. doi: 10.1038/s41586-022-04502-w. Epub 2022 Mar 16.
4
Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease.真菌菌群诱导的 IgA 抗体调节肠道共生真菌，在克罗恩病中失调。
Nat Microbiol. 2021 Dec;6(12):1493-1504. doi: 10.1038/s41564-021-00983-z. Epub 2021 Nov 22.
5
Adaptive immunity induces mutualism between commensal eukaryotes.适应性免疫诱导共生真核生物之间的共生关系。
Nature. 2021 Aug;596(7870):114-118. doi: 10.1038/s41586-021-03722-w. Epub 2021 Jul 14.
6
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.上皮内质网应激调控保护性 IgA 应答。
Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186.
7
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.真菌肽毒素 Candidaysin 激活 NLRP3 炎症小体并导致单核吞噬细胞细胞溶解。
Nat Commun. 2018 Oct 15;9(1):4260. doi: 10.1038/s41467-018-06607-1.
8
IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis.口腔上皮细胞中的白细胞介素-17受体信号传导对于预防口咽念珠菌病至关重要。
Cell Host Microbe. 2016 Nov 9;20(5):606-617. doi: 10.1016/j.chom.2016.10.001. Epub 2016 Oct 27.
9
Paneth Cell Alterations in the Development and Phenotype of Crohn's Disease.克罗恩病发展过程中的潘氏细胞改变及其表型
Gastroenterology. 2017 Feb;152(2):322-326. doi: 10.1053/j.gastro.2016.10.003. Epub 2016 Oct 8.
10
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization.共生细菌对HIF-1α和LL-37的激活可抑制白色念珠菌的定植。
Nat Med. 2015 Jul;21(7):808-14. doi: 10.1038/nm.3871. Epub 2015 Jun 8.
Zotero 插件